CD79A Antibody (HM57)

Product Specs
ItemCD79A Antibody (HM57) - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $429.00Supplier Page View Company Product Page
Catalog NumberNB100-64347
NCBI Gene AliasesMB-1, MB1, IGA, IGAlpha
ImmunogenSynthetic peptide corresponding to 202-216 amino acid sequence of human mb-1
Concentration1.0 mg/ml
Conjugate/TagUnconjugated
Quantity0.1 mg (also 0.025 mg)
TargetCD79A
HostMouse
CloneHM57
IsotypeIgG1
FormatPBS
ReactivityAvian - Chicken,Bovine,Canine,Human
ClonalityMonoclonal
ApplicationsIF/IHC,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen
NCBI Full Gene NameCD79a molecule
PurityProtein A purified
Research AreaAdaptive Immunity, Cell Biology, Immunology
Antibody TypePrimary Antibodies
StorageStore at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: NB100-64347 recognizes an epitope within the cytoplasmic domain of CD79a. CD79a, also known as mb-1, is a 45kD protein that is expressed by B lymphocytes during differentiation from early pre-B cell stage through to plasma cells. The CD79a molecule associates with CD79b (B29) to form a heterodimer that is non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex. The CD79a/CD79b heterodimers are also necessary for intracellular signalling following antigen-binding to surface immunoglobulin. Clone HM57 has been reported to work in western blotting applications.

Sizes Available: 0.1 mg (also 0.025 mg)

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Questions and Answers

Can this antibody be used to study B cells in lung tissue?

Yes, the CD79A antibody (HM57) has been cited in research involving B cells, specifically in the context of precision-cut lung slices where it was used to identify CD19+ B cells. This suggests its utility in studying B cell populations in lung tissue.

What species can I use this antibody on for my experiments?

The CD79A antibody is reactive with multiple species, including humans, canines, bovines, and chickens. This broad reactivity allows for its application in various animal models as well as human studies.

Is there any evidence of this antibody being used in immunohistochemistry?

Yes, the CD79A antibody has been shown to work in immunohistochemistry applications, as indicated by its use in studies that involve the identification of specific cell types within tissue sections.

What specific epitope does this antibody recognize?

The CD79A antibody recognizes an epitope within the cytoplasmic domain of the CD79a molecule, which is crucial for its role in B cell receptor signaling and function.

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4DNeuromuscular disorders : NMDJanuary 1, 0001"Skedsmo FS, Espenes A, Tranulis MA, Matiasek K, Gunnes G, Bjerkås I, Moe L, Røed SS, Berendt M, Fredholm M, et al."

(2) Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft DysfunctionTransplantationJanuary 1, 0001"Lynch TJ, Ahlers BA, Swatek AM, Ievlev V, Pai AC, Brooks L, Tang Y, Evans IA, Meyerholz DK, Engelhardt JF, et al."

(3) Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomicsExperimental & molecular medicineJanuary 1, 0001"Zhu J, Fan Y, Xiong Y, Wang W, Chen J, Xia Y, Lei J, Gong L, Sun S, Jiang T."

(4) "Cellular infiltration, cytokines, and histopathology of skin lesions associated with different clinical forms and stages of naturally occurring lumpy skin disease in cattle""Comparative immunology, microbiology and infectious diseases"January 1, 0001"Badr Y, Noreldin AE, Elewa YHA, Ahmed MS, Inoshima Y, Baker NM, Aamer WN, Abas OM, Nayel M, Rahman MM, et al."

(5) Neuropeptide stimulation of physiological and immunological responses in precision-cut lung slicesPhysiological reportsJanuary 1, 0001"Patlin B, Schwerdtfeger L, Tobet S."eBioscience,Cy3 anti‐rat 1:500,AB_2338253,112‐166‐003 Jackson ImmunoResearch,B cells CD79,AB_962641,NB10064347 Novus Biologicals,Cy3 anti‐rabbit 1:500,AB_2338008,111‐166‐045 Jackson ImmunoResearch,B cells Peripherin,AB_90725,Ab1530

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5/26/2023Novus Biologicals' CD79a Antibody Works for IHC Mehmet Fatih BozkurtIt is classical CD79a antibody. It stains B cell lymphocyte and some plasma cells. An antibody that also has affinity (probably nonspecific) for smooth muscle cells.