Kainic acid, prototypic kainate receptor agonist ab120100 from Abcam

Product Specs
ItemKainic acid, prototypic kainate receptor agonist
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120100
Quantity1 mg, 10 mg, 50 mg
Purity0.99
TypeActivator/Agonist
Molecule NameKainic acid

Questions and Answers

Can this kainic acid be used to induce seizures in animal models?

Yes, kainic acid has been shown to effectively induce seizures in various animal models. For instance, in studies, it was administered intraperitoneally to rats and mice to establish models of status epilepticus, allowing researchers to investigate seizure mechanisms and potential treatments (, , ).

What are some specific applications of kainic acid in research?

Kainic acid has been utilized in studies to explore synaptic deafferentation and repair mechanisms in vestibular systems, as well as to investigate the effects of deep brain stimulation on seizure activity in the hippocampus (, ). It has also been used to assess the impact of various treatments on seizure severity and cognitive impairment in epilepsy models ().

Is there any evidence of kainic acid affecting synaptic plasticity?

Yes, kainic acid has been implicated in studies examining synaptic plasticity. For example, research indicated that kainic acid administration can lead to alterations in synaptic function and plasticity in the hippocampus, affecting long-term potentiation and depression ().

What dosage of kainic acid is typically used in experimental settings?

Dosages of kainic acid can vary depending on the specific experimental design. In studies, doses such as 5 mg/kg and 10 mg/kg have been commonly used for inducing seizures in rodent models (, ).

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(1) Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1Advanced ScienceMay 29, 2026Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiaostatus epilepticus, mice received a single intraperitoneal (i.p.) injection of kainic acid (KA; Abcam, ab120100) at a dose of 20 mg/kg. 5.5.2 Chronic Spontaneous Recurrent Seizures (SRS) To establish a model of

(2) Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy ProgressionAdvanced ScienceJanuary 1, 2026Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, et al.Precision drilling at these coordinates was conducted using a 0.5 mm skull drill. KA (10 mg mL−1, #ab120100, Abcam, United States) was administered intrahippocampally using a Hamilton syringe attached to a Quintessential

(3) Hippocampal Oligodendrocytes Regulate Mossy Fiber Development Involved in Epileptic ResponsesNeuroscience BulletinJuly 17, 2025Chunxia Jiang, Yunan Hu, Feng Zhang, Mengsheng Qiu, Xiaofeng Zhaofreely-moving mice as a baseline. The mice received an intraperitoneal injection of kainic acid (KA; Abcam, ab120100, 25 mg/kg). Then, EEG was recorded for an additional 2 h after KA treatment. EEG was recorded using

(4) Neuronal activity modulates the expression of secretagogin, a Ca2+ sensor protein, during mammalian forebrain developmentActa Physiol (Oxf)March 31, 2025János Hanics, Evgenii O. Tretiakov, Roman A. Romanov, Anna Gáspárdy, Zsófia Hevesi, Robert Schnell, Tibor Harkany, Alán Alpárhttps://eugot.github.io/Hanics_2024/01A‐eda.html. 2.4 Kainate administration Kainic acid (Abcam, ab120100) was dissolved in physiological saline at a concentration of 5 mg/mL. Adult male mice (C57BL/6J, n =

(5) Chemogenetics with PSAM(4)-GlyR decreases excitability and epileptiform activity in epileptic hippocampusGene therapyMarch 1, 2025Gonzalez-Ramos A, Berglind F, Kudláček J, Rocha ER, Melin E, Sebastião AM, Valente CA, Ledri M, Andersson M, Kokaia M.AP −2.0, ML + 1.6, DV −1.9. A total of 45 nl of KA solution (20 mM i.e., total dose 0.9 nM KA; Abcam ab120100) was injected at a rate of 25 nl/min followed by 3 min of waiting time before retraction of the glass

(6) Low-Frequency Stimulation at the Ventromedial Hypothalamus Exhibits Broad-Spectrum Efficacy Across Models of EpilepsyCNS Neurosci TherFebruary 9, 2025Shuang Zou, Yiwei Gong, Mengqi Yan, Zhijian Yuan, Minjuan Sun, Shuo Zhang, Yuanzhi Yang, Xiongfeng Guo, Lan Huang, Fan Fei, et al.focal‐onset seizure models were established according to our previous studies [22, 23]. Briefly, KA (ab120100, Abcam, 0.25 μg in 0.5 μL saline) was injected into the right CA3 or M1 cortex using an infusion needle

(7) Regulation of MAP2, GFAP, and calcium in the CA3 Region Following Kainic Acid Exposure to organotypic hippocampal slice cultureF1000ResJanuary 3, 2025Machlusil Husna, Kusworini Handono, Hidayat Sujuti, Aulanni'am Aulanni'am, Ettie Rukmigarsarinamely the untreated group and the kainate group. The kainate group was treated with kainic acid (Abcam, AB120100) at a dose of 8 μM by bath application for 48 h and put in an incubator at 37 oC. After that, both groups

(8) Posterior Basolateral Amygdala is a Critical Amygdaloid Area for Temporal Lobe EpilepsyAdvanced ScienceDecember 1, 2024Yan‐Hui Sun, Bo‐Wu Hu, Li‐Heng Tan, Lin Lin, Shu‐Xia Cao, Tan‐Xia Wu, Hao Wang, Bin Yu, Qin Wang, Hong Lian, et al.USA) was injected intraperitoneally. 0.5 h after CNO injection, KA (0.25 µg in 500 nl saline, Abcam, ab120100, UK) was administered into the right CA1 region (AP = −2.10 mm; ML = −1.50 mm; DV = −1.60 mm) to induce

(9) Single-cell, single-nucleus and xenium-based spatial transcriptomics analyses reveal inflammatory activation and altered cell interactions in the hippocampus in mice with temporal lobe epilepsyBiomarker ResearchSeptember 13, 2024Quanlei Liu, Chunhao Shen, Yang Dai, Ting Tang, Changkai Hou, Hongyi Yang, Yihe Wang, Jinkun Xu, Yongchang Lu, Yunming Wang, et al.injected intraperitoneally to anaesthetize the animals. For the mice in the TLE group, 200 nl of 1% KA (ab120100, Abcam, United States) was stereotaxically injected into the CA1 region of the hippocampus (AP -2.0

(10) Septal stimulation attenuates hippocampal seizure with subregion specificityEpilepsia OpenAugust 1, 2024Qingyang Zhang, Yu Wang, Fei Wang, Dongxiao Jiang, Yingjie Song, Lin Yang, Mengdi Zhang, Yi Wang, Yeping Ruan, Jiajia Fang, et al.After 1 week of recovery, mice were administered 500 nL KA (0.5 μg/μL, dissolved in 0.9% saline, Cat# ab120100, Abcam, Cambridge, UK) through the cannula over 5 min with a 1‐μL microliter syringe. EEGs were recorded

(11) Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates EpileptogenesiseNeuroMay 3, 2024Alicia M. Hall, Noriko Kamei, Manlin Shao, Hyun-Seung Mun, Kevin Chen, Yuncai Chen, Tallie Z. BaramDudek (Hellier and Dudek, 2006). Briefly, intraperitoneal injections of 5 mg/kg of KA (Abcam; catalog #ab120100) were repeated to reach and maintain SE for 3 h (two rats received half doses, 2.5 mg/kg). We continuously

(12) Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates EpileptogenesiseNeuroMay 3, 2024Alicia M. Hall, Noriko Kamei, Manlin Shao, Hyun-Seung Mun, Kevin Chen, Yuncai Chen, Tallie Z. BaramDudek (Hellier and Dudek, 2006). Briefly, intraperitoneal injections of 5 mg/kg of KA (Abcam; catalog #ab120100) were repeated to reach and maintain SE for 3 h (two rats received half doses, 2.5 mg/kg). We continuously

(13) Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firingCommunications BiologyOctober 11, 2023David Skrabak, Helmut Bischof, Thomas Pham, Peter Ruth, Rebekka Ehinger, Lucas Matt, Robert Lukowskiseverity in Slack+/+ and Slack−/− mice were assessed by using the KA-based model of acute epilepsy. KA (ab120100, Abcam, Berlin, Germany) dissolved in sterile saline was intraperitoneally applied to randomly selected

(14) Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsyCNS Neuroscience & TherapeuticsOctober 1, 2023Jianchen Fan, Xinyan Dong, Yejiao Tang, Xuehui Wang, Donghui Lin, Lifen Gong, Chen Chen, Jie Jiang, Weida Shen, Anyu Xu, et al.following the induction of epileptic seizure, which received an i.p. injection of 18 mg/kg kainic acid (ab120100, Abcam). Each group consisted of 6 SD rats. The Racine scores were applied to rate seizure severity:

(15) Combinatorial gene therapy for epilepsy: Gene sequence positioning and AAV serotype influence expression and inhibitory effect on seizuresGene TherapyApril 7, 2023Esbjörn Melin, My Andersson, Casper R. Gøtzsche, Jenny Wickham, Yuzhe Huang, Julia Alicja Szczygiel, Arnie Boender, Søren H. Christiansen, Lars Pinborg, David P. D. Woldbye, et al.preparation and induction of SE KA was prepared freshly the same day as SE induction. 50 mg of KA (Abcam, ab120100) was dissolved in 4 ml of saline and adjusted with 1 M NaOH to a pH of 7.4, in order to reduce a pain

(16) Activated astrocytes attenuate neocortical seizures in rodent models through driving Na(+)-K(+)-ATPaseNature communicationsNovember 21, 2022Zhao J, Sun J, Zheng Y, Zheng Y, Shao Y, Li Y, Fei F, Xu C, Liu X, Wang S, et al.experiments. Intra-cortical KA model After surgery recovery, KA (300 ng in 600 nl sterile saline, ab120100, Abcam) was injected into M1 with an infusion needle (62203, RWD Life Science) through the guide cannula

(17) Glutamate can act as a signaling molecule in mouse preimplantation embryos†Biology of reproductionOctober 11, 2022Špirková A, Kovaříková V, Šefčíková Z, Pisko J, Kšiňanová M, Koppel J, Fabian D, Čikoš Š.and kainic acid (KA) [(2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid; ab120100; Abcam UK] at 5 mM, 2 mM, 1 mM, 0.5 mM, and 0.3 mM concentrationsSpecific metabotropic glutamate receptor

(18) Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosisJournal of neuroinflammationSeptember 14, 2022Dong X, Fan J, Lin D, Wang X, Kuang H, Gong L, Chen C, Jiang J, Xia N, He D, et al.groups: control group (with saline intraperitoneal (ip) injection), KA group (with 14 mg/kg kainite acid (ab120100, Abcam, USA) ip injection), and KA + Cap group (with 50 mg/kg captopril ip injection). Seizure severity

(19) Discrete subicular circuits control generalization of hippocampal seizuresNature CommunicationsAugust 25, 2022Fan Fei et al.withdrawal. For KA injection, mice were anesthetized with ~2% isoflurane. KA (0.25 μg in 0.5 μL saline, ab120100, Abcam) was injected into the dorsal CA1 (AP −2.1 mm; L −1.2 mm; V −1.6 mm) with a glass micropipette

(20) Nanoengineered on-demand drug delivery system improves efficacy of pharmacotherapy for epilepsyScience AdvancesJanuary 14, 2022Di Wu et al.were anesthetized with ~2% isoflurane and mounted in a stereotaxic apparatus; KA (0.5 mg/ml, 0.5 μl; ab120100, Abcam) was injected into the dorsal hippocampus (antero-posterior, −2.0 mm; lateral, −1.2 mm; ventral,

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9/17/2023Great Prototypic Kainate Receptor Agonist From Abcam Bruce WangKainate receptors have direct actions on intrinsic cell excitability in the hippocampus and modulate both glutamatergic and GABAergic synaptic transmission in a number of brain regions. Because of its... Read Review

Kainic acid, prototypic kainate receptor agonist from Abcam

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Kainic acid, prototypic kainate receptor agonist from Abcam

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