MMR/CD206 Antibody AF2535 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMMR/CD206 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF2535
NCBI Gene AliasesCLEC13D, hMR, MMR, CLEC13DL, CD206, MR, bA541I19.1, MRC1L1
ApplicationsIHC-Pr,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunofluorescence,Immunocytochemistry,CyTOF-ready
Conjugate/TagUnconjugated
TargetMMR/CD206
IsotypeIgG
ReactivityHuman,Mouse,Rat,Transgenic Mouse
HostGoat
Quantity100 ug (also 25 ug)
NCBI Full Gene Namemannose receptor C-type 1, mannose receptor, C type 1
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse MMR/CD206, Leu19-Ala1388, Accession # Q2HZ94
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse MMR/CD206 in direct ELISAs and Western blots. In direct ELISAs, less than 45% cross-reactivity with recombinant human MMR is observed.

Sizes Available: 100 ug (also 25 ug)

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Questions and Answers

Can this antibody be used for immunohistochemistry in lung cancer studies?

Yes, the MMR/CD206 antibody has been utilized in immunohistochemical staining to identify positive cells in both tumor and non-tumor regions of the lung, as demonstrated in a study investigating the immunosuppressive environment in lung cancer models ().

What is the specificity of this antibody when used in mouse models?

The MMR/CD206 antibody has been shown to specifically detect mouse MMR/CD206 with less than 45% cross-reactivity with recombinant human MMR in direct ELISAs and Western blots, making it suitable for studies involving mouse models ().

How has this antibody been applied in research involving macrophage polarization?

The MMR/CD206 antibody has been employed in studies to assess macrophage polarization, particularly in the context of microglial activation and polarization in models of cerebral ischemia, where it was used to evaluate the expression levels of M2 markers in microglial cells (; ).

Is there any evidence of this antibody being used in studies related to tumor-associated macrophages?

Yes, the MMR/CD206 antibody has been referenced in studies examining tumor-associated macrophages, particularly in the context of glioblastoma, where it was used to analyze the immunosuppressive characteristics of macrophages in hypoxic tumor environments ().

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

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2/23/2022Good CD206 Antibody for Immunostaining Kumar SubramaniThe aim of our experiments is to look for the macrophages marker CD206.