SOX3 Antibody AF2569 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSOX3 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $489.00Supplier Page View Company Product Page
Catalog NumberAF2569
NCBI Gene AliasesSOXB, PHPX, PHP, MRGH, GHDX
ApplicationsFlow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry
Conjugate/TagUnconjugated
IsotypeIgG
TargetSOX3
HostGoat
Quantity100 ug (also 25 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityHuman,Mouse,Transgenic Mouse
NCBI Full Gene NameSRY-box transcription factor 3
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human SOX3, Met1-Leu230, Accession # P41225
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human SOX3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) SOX2, rhSOX7, rhSOX10, and rhSOX17 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) RUNX proteins and CBFβ create an interconnected network of transcriptional regulation in the male germline†Biology of ReproductionApril 13, 2026Mustika Rahmawati, Carson J Black, Danika D Dalvi, Amanda J Brown, Kassie M Stadler, Tia M Hoisington, Nathan C Law1:250Flow cytometry 1:125 Goat anti-cKIT,"R&D Systems, AF1356",IF,1:125 Goat anti-SOX3,"R&D System, AF2569",IF,1:250 Goat anti-GFR⍺1,Fisher - AF560,IF,1:250 Rat anti-TRA98,"Abcam, ab82527",IF,1:500 "Rat anti-Ki67,

(2) Aberrant medial ganglionic eminence (MGE) GABAergic neurogenesis contributes to Huntington's disease pathogenesisNeurobiology of DiseaseApril 1, 2026Aldrin E. Molero, Gnanapackiam S. Devakanmalai, Yagiz M. Altun, Teresa Jover-Mengual, Junya Zhang, Nusrat Khan, Mark F. Mehleranti-Satb1, 1:200, Santa Cruz Biotechnology, #sc-376,096), Sox3 (Goat anti-Sox3, 1:500, R&D Systems, #AF2569), SST (rabbit anti-SST, 1:1000, BMA Biomedicals, #T-4103), and VIP (mouse anti-VIP, 1:200, R&D Systems,

(3) BRCA1 preserves genome integrity during the formation of undifferentiated spermatogoniaEMBO ReportsMay 28, 2025Peng Li, Licun Song, Longfei Ma, Chunsheng Han, Lejun Li, Lin-Yu Lu, Yidan Liu,R&D Systems,AF2944 Goat anti-KIT,R&D Systems,AF1356 Goat anti-GFRα1,R&D Systems,AF560 Goat anti-SOX3,R&D Systems,AF2569 Rabbit anti-cleaved PARP1 (Asp214),"Cell Signaling Technology,",9544 Rabbit anti-phospho-Histone H3 (Ser10

(4) Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesisReproduction (Cambridge, England)January 1, 2023Prakash Yadav R, Leskinen S, Ma L, Mäkelä JA, Kotaja N.(1:200, Millipore, ABD41), WDHD1 (1:200, A301-141A-T), GFRa1 (AF560, R&D Systems, 1:250) and SOX3 (AF2569, R&D Systems, 1:200) and DNMT3A (IMG-268A, Imgenex/Novus, 1:200). Following washes, the tubules were

(5) Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumoursFrontiers in cell and developmental biologyJanuary 1, 2023Whiley PAF, Nathaniel B, Stanton PG, Hobbs RM, Loveland KL.,R&D Systems,1:250,NA GILZ,Rat,14–4033–82,Invitrogen,1:250,RRID:AB_1311225 LIN28A,Rabbit,#8641,Cell Signalling,1:500,RRID:AB_10997528 GCNA,Rat,ab82527,Abcam,1:500,RRID:AB_1659152 SOX3,Goat,AF2569,R&D Systems,1:250,RRID:AB_2239933 LAMININ,Rabbit,L9393,Sigma-Aldrich,1:200,RRID:AB_477163 CYP11A1,Rabbit,,gift

(6) Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic agesCell reportsMarch 22, 2022Sun Y, Wang L, Zhu T, Wu B, Wang G, Luo Z, Li C, Wei W, Liu Z.

(7) An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogoniaCell reportsFebruary 16, 2021Suzuki S, McCarrey JR, Hermann BP.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies "Goat anti-SOX3 antibody (0.8 μg/mL); Figures 2, 3, 5, and S3–S5",R&D Systems,RRID: AB_2239933 Cat# AF2569 Goat anti-c-KIT antibody (4 μg/mL); Figures 5 and S3–S5,R&D Systems,RRID: AB_354750 Cat# AF1356 "Mouse

(8) The Nestin neural enhancer is essential for normal levels of endogenous Nestin in neuroprogenitors but is not required for embryo developmentPloS oneJanuary 1, 2021Thomson E, Dawson R, H'ng CH, Adikusuma F, Piltz S, Thomas PQ.and contrast using Adobe Photoshop v7 (Adobe Systems). Antibodies used were Anti-SOX3 (R&D Systems, AF2569, 1/200), Anti-Nestin (Abcam AB82375, 1/1000), Anti-CD31 (BD Pharmingen 550274, 1/100). Secondary antibodies,

(9) DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogoniaNature communicationsMay 23, 2019Legrand JMD, Chan AL, La HM, Rossello FJ, Änkö ML, Fuller-Pace FV, Hobbs RM.R&D Systems, #AF1356); rabbit anti-ILF3 (1:500, Abcam, #ab92355); goat anti-SOX3 (1:250, R&D Systems, #AF2569); rabbit anti-VASA (1:250, Cell Signalling Technology, #8761); rabbit anti-SOX9 (1:1000, Millipore,

(10) GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenanceDevelopment (Cambridge, England)September 18, 2018La HM, Chan AL, Legrand JMD, Rossello FJ, Gangemi CG, Papa A, Cheng Q, Morand EF, Hobbs RM.Primary antibodies were as follows: goat anti-PLZF (AF2944, 1:500), anti-GFRα1 (AF560, 1:250), anti-SOX3 (AF2569, 1:250), anti-c-KIT (AF1356, 1:250) and anti-E-cadherin (AF748, 1:250) (all R&D Systems); rabbit anti-phospho-RPS6

(11) An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesiseLifeNovember 15, 2017Zhang H, Wang L, Wong EYM, Tsang SL, Xu PX, Lendahl U, Sham MH.immunostaining was performed using anti-Sox2 (1/500, GT15098-100, Neuromics, Minnesota, USA), anti-Sox3 (1/500, AF2569, R and D systems, Minnesota, USA), anti-Jagged1 (1/300, Ts1.15h, DSHB, Iowa, USA) and anti-E-cadherin

(12) Identification of highly conserved putative developmental enhancers bound by SOX3 in neural progenitors using ChIP-SeqPloS oneJanuary 1, 2014McAninch D, Thomas P.chromatin was immunoprecipitated by a goat polyclonal antibody raised against human SOX3 (R&D systems, AF2569). DNA was recovered by reversing crosslinks, and purified by PCR clean-up kit (QIAGEN). Three independent

(13) Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic micePloS oneJanuary 1, 2012Lee K, Tan J, Morris MB, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R, et al.as described previously [23]. Antibodies and dilutions were: goat anti-SOX3 (R&D systems cat. no.: AF2569, 1∶100), rabbit anti-EGFP (Abcam cat. no.: ab290, 1∶1000), rabbit anti-RF (kindly donated by A. Meiniel;

(14) Identification of SOX3 as an XX male sex reversal gene in mice and humansThe Journal of clinical investigationJanuary 1, 2011Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, et al.

(15) SOX3 promotes generation of committed spermatogonia in postnatal mouse testesScientific reportsJanuary 1, 0001"McAninch D, Mäkelä JA, La HM, Hughes JN, Lovell-Badge R, Hobbs RM, Thomas PQ."described16,20. Antibodies Antibodies are detailed previously16,20,30,31,33, including αSOX3 (R&D Systems AF2569), αDNMT3A (Novus Biologicals 64B1446), αDNMT3B (Novus Biologicals 52A1018), α c-KIT (Cell Signaling Technologies

(16) Identification of dynamic undifferentiated cell states within the male germlineNature communicationsJanuary 1, 0001"La HM, Mäkelä JA, Chan AL, Rossello FJ, Nefzger CM, Legrand JMD, De Seram M, Polo JM, Hobbs RM."anti-mouse/rat PDX1 (AF2517, 1:250), anti-PLZF (AF2944, 1:500), anti-LIN28A (AF3757, 1:500) and anti-SOX3 (AF2569, 1:250) (R&D Systems), rabbit anti-mCherry (ab167453, 1:2000), anti-OCT4 (ab19857, 1:500), anti-SALL4

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(1)

3/1/2022Good SOX3 Antibody for Immunostaining James CarrollConstructed mice tissue immunostained for sox3. Signal works well, expression increased compared to WT control mice.

SOX3 Antibody

SOX3 Antibody

SOX3 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (16)

Reviews

SOX3 Antibody from R&D Systems, a Bio-Techne Brand

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