Evaporative light scattering detectors (ELSD) provide comprehensive information about analytes, including measurement of particle size below a nanometer, molecular weight, and zeta potential. ELSD in particular is considered a universal tool in HPLC due to its wide range of applications. These detectors are vital instruments in many life science areas, including the expanding biotech, proteomics, and biologics environments. When choosing a detector, take note of how it manages semi-volatile compounds and gradients. Although ultimate sensitivity tends to be similar for all instruments, dynamic range, baseline stability, and peak width and shape all vary based on system design. Highlights include equipment optimized for accurate, easy-to-perform protein characterization, multiple detection methods available on one instrument, fast changeover for wet/dry measurement, and ELSDs with sub-ambient operation for enhanced detection.
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