ExionLC™ 2.0 and ExionLC™ 2.0+ Systems from SCIEX

Product Specs
ItemExionLC™ 2.0 and ExionLC™ 2.0+ Systems
CompanySCIEX
Price Get Pricing Get Quote for this Product
Catalog NumberExionLC
QuantityEA
TypeHigh-flow LC
CapacityUp to 8 x 12.5 cm columns
Maximum PressureEXIONLC 2.0 system:12,500 psi (860 bar) ; EXIONLC 2.0+ system: 18,000 psi (1240 bar)
DetectionPDA, high sensitivity PDA and MWD

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SCIEX

500 Old Connecticut Path

Framingham, MA 01701

United States

Phone: 1 877-740-2129

Email: sales.americas@sciex.com

Company Profile

Website: www.sciex.com

Website: www.lifesciences.danaher.com/us/en/products/brands/sciex

(1) An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degenerationMolecular Therapy Nucleic AcidsJune 16, 2026Shun-Yun Cheng, Delaney Giguere, San Kim, Johanna M. Seddon, Jillian Caiazzi, Katherine Gross, Nicholas McHugh, Dimas Echeverria, Julia F. Alterman, Heather Gray-Edwards, et al.Helsinki, Finland). Lipid profiling for Figures 4D and 4E was performed by Caymen Chemicals on a Sciex ExionLC Integrated System. Oligonucleotide synthesis Oligonucleotides were synthesized by phosphoramidite

(2) Ultraviolet radiation reshapes the metabolome of skin commensal bacteria, influencing AhR signaling and barrier functionApplied and Environmental MicrobiologyApril 22, 2026Steven D. Mercer, Abigail Elias, George Taylor, Geoff S. Briggs, Michael Bell, Andrew J. McBain, Catherine A. O'Neillcalibrations required R² ≥ 0.99. Targeted LC–MS (tryptophan metabolites) Analyses were performed on a SCIEX ExionLC coupled to a SCIEX 7600 ZenoTOF Q-TOF (positive ESI). Ten-microliter injections were separated on a

(3) Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant Paris polyphyllaSynth Syst BiotechnolApril 21, 2026Hizar Subthain, Fei Guo, Chengjie Zhang, Peng Fang, Lingli Zhang, Qixuan Su, Dandan Tang, Luping Chi, Changning Liu, Vlada B. Urlacher, et al.the leaf sample extracts were analyzed by ultra high-performance liquid chromatography system (SCIEX, ExionLC, UHPLC) coupled with a triple quadrupole mass spectrometer (SCIEX Triple Quad 5500+ QTrap Ready). Chromatographic

(4) Long-Term Static Cultivation Alters Lipid Metabolism and Bioenergetic Capacity in A549 CellsInt J Mol SciApril 10, 2026Ivana Ďurišová, Lucia Šofranková, Aleš Kvasnička, Miroslav Baláž, Ivana Fábryová, David Friedecký, Mária Balážovámore, was used to semiquantify lipids in the cell medium extracts. The liquid chromatography (Sciex ExionLC system (SCIEX, Framingham, MA, USA) with Waters Acquity BEH C8 2.1 mm, 100 mm, 1.7 μm column (Waters

(5) Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancerCancer MetabApril 4, 2026Nneka E. Mbah, Damien Sutton, Hanna S. Hong, Rashi Singhal, Rosa E. Menjivar, Matthew D. Perricone, Heather Giza, Peter Sajjakulnukit, Amy L. Myers, Zeribe C. Nwosu, et al.1‐butanol/methanol 1:1 (v/v). For targeted LC-MS/MS, extracted lipid samples (20 µL) were injected onto a Solex ExionLC Integrated System coupled to a Sciex QTrap 6500 + mass spectrometer. Lipid separation was performed

(6) SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axisCell Death & DiseaseMarch 23, 2026Yu Duan, Yingchun Luo, Xuejie Han, Hui Yu, Hanwen Liu, Yun Zhou, Yunlong Gao, Qian Xu, Ying Wei, Ruoxin Min, et al.collected for targeted oxylipidomic analysis. Oxylipins were quantified using UHPLC–MRM–MS/MS on an EXIONLC System (SCIEX) coupled to a SCIEX 6500 QTRAP+ mass spectrometer equipped with an IonDrive Turbo V electrospray

(7) An In Vitro Functional Characterization of the Cholesterol-Transforming Blautia hominis Strain HA2291 Isolated from the Human GutNutrientsMarch 10, 2026Warren Chanda, He Jiang, Shuang-Jiang Liure-dissolved with 1 mL methanol, and analyzed by Ultra-High Performance liquid chromatography system (SCIEX, ExionLC, UHPLC) coupled with a triple quadrupole mass spectrometer (SCIEX Triple Quad 5500+ QTrap Ready, AB

(8) MAGL Inhibition Relieves Psoriasiform Inflammation and Pruritus Via Modulation of ALOX12-12-HETE Axis in MiceInflammationMarch 3, 2026Shiying Lin, Xin Liu, Jian Jiang, Wenqiang Ge, Qingxiao Tao, Suwen Liu, Ouyang Zhanmu, Yang Yang, Man Li, Hongxiang ChenSolid-Phase Extraction and filtered to obtain a clear supernatant. Chromatographic separation was performed using an EXIONLC System (Sciex) equipped with a Waters ACQUITY UPLC BEH C18 column (150 × 2.1 mm, 1.7 μm, Waters). Isocratic

(9) Comparative Metabolomics and Lipidomics of Meat from Duroc × Guangdong Small-Eared Spotted Pigs and Commercial Duroc × (Landrace × Yorkshire) PigsFoodsMarch 2, 2026Wenwen Liu, Shuilian Liang, Lu Xiao, Qiwei Guan, Jie Zhao, Xue Li, Yan Chen, Xu Wang0.22 μm membrane and moved to vials for LC–MS analysis. Lipidomics analysis was performed using an ExionLC ultra-high performance liquid chromatography system coupled with a mass spectrometer (QTRAP 6500+, SCIEX,

(10) Association between PFAS compounds in follicular fluid and POR and the intervention effect of Qizi Yusi Tang: a study based on targeted PFAS quantification analysisFront Endocrinol (Lausanne)February 27, 2026Hengbing Li, Jiacheng Li, Wenjing Jiang, Xin Hu, Zizhen Guo, Jingyan Song, Zhengao Sun2058-94-8); Perfluorodecanoic acid (PDA) (J&K Scientific, 335-76-2); 6500 Q-trap mass spectrometer (SCIEX); ExionLC™ System for UHPLC (SCIEX); Fresco™ 17 Microcentrifuge(Thermo Fisher Scientific); BSA124S-CW Analytical Balance

(11) Development of a competitive immunoassay platform for quantifying the oligonucleotide products of nucleotide excision repair in UV-irradiated cellsNucleic Acids ResearchFebruary 27, 2026Geun Hoe Kim, Ha-Jeong Kwon, Youngmin Kim, Michael G Kemp, Jun-Hyuk ChoiThe analysis was performed using a SCIEX 6500+ Triple Quadrupole Mass Spectrometer coupled with an ExionLC system. Analytes were separated on a Hypersil Gold C18 column (150 × 2.0 mm) using a mobile phase consisting

(12) Ly93 Inhibits Sphingomyelin Synthesis and Attenuates Inflammation and Injury in Dry Eye Conjunctival OrganoidsInvestigative Ophthalmology & Visual ScienceFebruary 27, 2026Qiankun Chen, Yuan Wei, Leying Wang, Junqi Liang, Jinding Pang, Yiping Han, Ahyan Ilman Qudsi, Qingfeng Liangliquid chromatography-tandem mass spectrometry analysis.20 The sample extracts were analyzed using a UPLC system (ExionLC) coupled to a QTRAP 6500+ mass spectrometer (Sciex) equipped with an electrospray ionization source

(13) Recovery and Stability of Omadacycline 150-mg Crushed Tablets Dispersed in Food or Water and Administered via Nasogastric TubeOpen Forum Infectious DiseasesFebruary 17, 2026Chenlin Hu, Ricky Huynh-Phan, Kevin M Rodriguez Robles, Taryn A Eubank, Kevin W Gareya diluted sample from the omadacycline tablet experiments described above was analyzed in the SCIEX ExionLC liquid chromatography system coupled with a QTRAP 5500 mass spectrometer (SCIEX), according to our previously

(14) Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer PatientsInternational Journal of Molecular SciencesFebruary 17, 2026Aleksandra Arsic, Ales Kvasnicka, David Friedecky, Nebojsa Ivanovic, Maja Milosevic, Vesna VucicAnalysis Chromatographic separation was performed using an ultra-high-performance liquid chromatography (UHPLC) ExionLC system (SCIEX, Framingham, MA, USA) coupled to a QTRAP® 6500+ mass spectrometer (SCIEX, Framingham,

(15) Investigating the Landscape of C6-Azaindole Side Chain on the Epoxymorphinan Skeleton via the Nitrogen Walk Concept: A Strategy to Enhance Drug-Like PropertiesJournal of Medicinal ChemistryFebruary 12, 2026Logan Neel, Hongguang Ma, Ahmed Reda, Mengchu Li, Rachael Flammia, Samuel Woodard, James C. Gillespie, Dana E. Selley, William L. Dewey, Piyusha P. Pagare, et al.reconstituted with 100 μL of mobile phase before LC-MS/MS analysis. Chromatography was performed on a Sciex ExionLC 2.0+ system coupled to a Sciex 6500 QTRAP with an IonDrive Turbo V source (Sciex, Ontario, Canada),

(16) Polyphenol-rich Chinese olive extracts attenuate lipid accumulation in HepG2 cells, accompanied by AMPK phosphorylation and miRNA alterationsFrontiers in NutritionFebruary 11, 2026Hong Wang, Bingqi Huang, Wenhong Zhao, Gongliang Liu, Weidong Bai-high performance liquid chromatography-tandem mass spectrometry The phenolic composition was determined using an ExionLC™ UHPLC system coupled to a QTRAP® 6,500+ triple quadrupole mass spectrometer (SCIEX, MA, United States).

(17) The Development and Characterization of a Nervonic-Acid-Rich Structured LipidMoleculesFebruary 10, 2026Guo-Ying Li, Hao-Duo Yang, Jian-Xin Wen, Yi-Xiang Sun, Wei-Min Zhang, Chin-Ping Tan, Yong-Jiang Xuet al. [37]. 3.5. TAG Composition Analysis via UPLC-MS TAG species were analyzed using an AB SCIEX ExionLC UPLC system (Framingham, MA, USA) coupled to a TripleTOF 5600+ mass spectrometer (SCIEX, Framingham,

(18) Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary DysplasiaAdvanced ScienceFebruary 6, 2026Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, et al.clear supernatant was subjected to UHPLC‐MS/MS analysis. The UHPLC separation was carried out using an EXIONLC System (Sciex), equipped with a Waters ACQUITY UPLC HSS T3 column (100 × 2.1 mm, 1.8 µm, Waters). The

(19) Fitness-for-Purpose Assessment of Methods for Glyphosate Determination in Food: Trade-Off Between Analytical Performance and Environmental ImpactFoodsFebruary 5, 2026Biancamaria Ciasca, Veronica Ghionna, Ivan Pecorelli, Emanuela Verdini, Antonio Moretti, Veronica Maria Teresa Lattanziodiluted with 2 mL of acetonitrile. Samples were injected into the LC-MS/MS system consisting of an ExionLC system interfaced to a 6500 QTRAP mass spectrometer (Sciex, Foster City, CA, USA) equipped with an electrospray

(20) The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkersFrontiers in Cellular NeuroscienceFebruary 4, 2026Baiyu Chen, Shimeng Chen, Juan Xiong, Miriam Kessi, Jing Peng, Fei Yin, Fang Heto avoid redundant fragmentation. For plasma lipidomics, UHPLC separation was conducted on a SCIEX ExionLC series system equipped with a Kinetex C18 column (2.1 mm × 100 mm, 1.7 μm; Phenomenex) maintained at

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