QX600 Droplet Digital PCR System from Bio-Rad

Product Specs
ItemQX600 Droplet Digital PCR System
CompanyBio-Rad
Price Get Pricing Get Quote for this Product
Catalog NumberQX600
QuantityEA
Capacity1 to 96 samples
DetectionAvalanche photodiodes, FAM (EvaGreen), HEX (VIC), Cy5, Cy5.5, ROX, and ATTO 590
Sample Volume20 µL
Dimensions(WxDxH) 66 x 52 x 29 cm (26 x 20 x 11 in)
ApplicationsOncology research, Gene Expression, Next generation sequencing (NGS) orthogonal testing, Cell and gene therapy, Food testing, Wastewater testing, Multiplexing, Absolute quantification
Wells96 wells
Channels6

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Bio-Rad

Bio-Rad Laboratories, Inc. Life Science Research Group 2000 Alfred Nobel Drive

Hercules, California 94547

United States

Phone: 800-424 6723
800-879 2289

Company Profile

Website: http://discover.bio-rad.com

(1) Global transcriptional changes across multiple isogenic C9orf72 patient iPSC-derived neuronsiScienceJune 19, 2026Aparna Sreeram, Desiree M. Baron, Alberto Brusati, Karly Stallworth, Jack Humphrey, John E. Landersprotocol. Droplets were generated either manually using DG8 cartridges (Bio-Rad 1864008) or via the QX600 Automated Droplet Generator (Biorad AutoDG) as per manufacturer’s instructions. PCR amplification was

(2) Human iPSC-Based Modeling Identifies Epigenetic Regulation at the KCNQ1 Locus During Early Islet Development That Contributes to Lower β-Cell MassDiabetesJune 1, 2026Anup K. Nair, Michael Traurig, Yunhua L. Muller, Divya Anup, Jeffrey R. Sutherland, Emma Grellinger, Nizhoni Henry, Kim Weidrich, Koushik Ponnanna Cheranda, Clifton Bogardus, et al.to confirm detection of interaction using the generated libraries. ddPCR ddPCR was done using the QX600 system (Bio-Rad) following manufacturer’s instructions using ∼200 ng input 3C library per reaction.

(3) Circulating Tumor DNA Monitoring in Patients with Uveal Melanoma Using Mutation-Agnostic Multiplex Drop-Off ddPCR AssaysAnal ChemMay 19, 2026Aurore Rampanou, Manuel Rodrigues, François-Clément Bidard, Nathalie Cassoux, Alexandre Matet, Anne Vincent-Salomon, Emmanuelle Jeannot, Ivan Bieche, Sergio Roman-Roman, Marc-Henri Stern, et al.(Madison, WI, USA) served as negative controls. The multiplex ddPCR assays were performed using the BioRad QX600 system (BioRad Laboratories, Hercules, CA, USA) with 900 nM of each primer, 400 nM of each probe, under

(4) The ribosomal RNA synthesis ratio biomarker in Mycobacterium ulcerans for drug activity evaluationInfect Dis PovertyMay 8, 2026Juan Calvet-Seral, Emma Sáez-López, Patricio R. López-Expósito, Santiago Ferrer-Bazaga, Juan José Vaquero, Santiago Ramón-García, Alfonso Mendoza-Losanaspecificity criterion (Fig. 1BI). Fluorophore probes were selected to allow differential detection in the QX600 system (Bio-Rad Laboratories, Inc., Hercules, USA) channels: Channel 1 for ETS1, Channel 2 for 23S rRNA,

(5) Surveillance on California dairy farms reveals multiple possible sources of H5N1 influenza virus transmissionPLoS BiolMay 5, 2026A. J. Campbell, Meredith Shephard, Abigail P. Paulos, Matthew D. Pauly, Michelle N. Vu, Chloe Stenkamp-Strahm, Kaitlyn Bushfield, Betsy Hunter-Binns, Orlando Sablon, Emily E. Bendall, et al.using an AutoDG (Bio-Rad), targets amplified using a thermal cycler (Bio-Rad), and quantified using the QX600 (Bio-Rad). Three ddPCR replicates were performed per sample, and the three wells were merged for analysis.

(6) Rapid identification of COVID wastewater surges in the absence of case datamSphereApril 28, 2026Victoria I. Verhoeve, Joshua Lambert, Amy Jones, Timothy Driscoll(RT-ddPCR) was carried out with the One-Step RT-ddPCR Advanced Kit for Probes (Bio-Rad Technologies) on a QX600 ddPCR system (Bio-Rad Technologies) using 5 µL of TNA as input. Total SARS-CoV-2 was measured using

(7) Bio-Rad and QIAGEN digital PCR platforms provide equivalent quantification for wastewater-based SARS-CoV-2 surveillanceApplied and Environmental MicrobiologyApril 22, 2026Thomas Clerkin, Steph Smith, Kevin Zhu, Denene Blackwood, Javier Gallard-Góngora, Drew Capone, Joe Brown, Rachel T. Noblecurrently dominate wastewater surveillance of SARS-CoV-2 in the United States: the Bio-Rad QX200 and QX600 droplet digital PCR (ddPCR) platform and the QIAGEN QIAcuity dPCR platform. The Bio-Rad QX200, released in 2013, uses

(8) DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCsNucleic Acids ResApril 20, 2026Nathan White, Yi-Ting Hu, John Alexander Chalk, Gavin Kurgan, Asma Naseem, Ellen Schmaljohn, Morgan Sturgeon, Alessia Cavazza, Adrian James Thrasher, Giandomenico Turchianousing the C1000 Touch™ Thermal Cycler with 96-Deep Well Reaction (Bio-Rad) and droplets read using a QX600 Droplet Reader (Bio-Rad). Droplet thresholds were manually set using QX Manager Software (Bio-Rad, Version

(9) MPXV replication and drug resistance in CNS of advanced HIV case at autopsyResearch SquareApril 9, 2026Daniel Chertow, Maria Charles, Sofia Romero Ferrufino, Sabrina Ramelli, Shane Gallogly, Claude Kwe Yinda, Divya Ahuja, Edwin Hayes, Morgan Pizzuti, Kevin Vannella, et al.100uL nuclease-free water. Three distinct MPXV gene targets in each sample were quantified using the QX600 AutoDG ddPCR System (Bio-Rad) (supplemental methods). DNA sequencing libraries were prepared, sequenced,

(10) Pediatric long COVID is characterized by myeloid CCR6 suppression and immune dysregulationJCI InsightApril 8, 2026Jon Izquierdo-Pujol, Núria Pedreño-Lopez, Tetyana Pidkova, Maria Nevot, Victor Urrea, Fernando Laguía, Francisco Muñoz-López, Judith Dalmau, Alba Gonzalez-Aumatell, Clara Carreras-Abad, et al.SARS-CoV-2 3′UTR (total), N (total), N genomic, and Nsg copies were quantified by droplet digital PCR (QX600, BioRad) (60–62). Statistics. Cell frequency, antibody levels, and neutralizing capacity in each group

(11) Wastewater surveillance reveals patterns of antibiotic resistance across the United StatesNature CommunicationsApril 1, 2026Sooyeol Kim, Alessandro Zulli, Elana M. G. Chan, Dorothea Duong, Rebecca Y. Linfield, Caroline E. M. McCormack, Bradley J. White, Marlene K. Wolfe, Alexandria B. Boehm, Amy J. PickeringAutomated Droplet Generator (BioRad #1864101, California, USA). Quantification was performed using a QX600 Droplet Digital PCR system (BioRad #17007769, California, USA). All assays were performed at an annealing temperature of 58 °C.

(12) Monitoring biological effects of somatic cell genome editingNature Reviews GeneticsApril 1, 2026Benjamin S. Freedman, Jeff W. M. Bulte, Bruce R. Conklin, Luke M. Judge, Melinda R. Dwinell, Aron M. Geurts, Madeleine J. Sitton, Vineet Mahajan, Samira Kiani, Charles A. Gersbach, et al.specificity of a given editing event48,50. Newer instruments, such as Qiagen’s QIAcuity One or BioRad’s QX600, incorporate additional fluorescent channels to facilitate detection of multiple editing outcomes in

(13) The 12 o’clock assay: an optimized dodecaplex droplet digital PCR assay for robust DNA methylation quantification and epigenetic clock-based age-predictionsClinical EpigeneticsMarch 24, 2026Ilef Hchaichi, Imène Garali, Alina-Madalina Popa, Antoine Daunay, Nicolas P. Tessier, Mourad Sahbatou, Lise M. Hardy, Aurore Rampanou, Hélène Blanché, Jean-François Zagury, et al.0.625 ng to 40 ng of converted DNA was used as template in multiplex ddPCR experiments performed on a QX600™ ddPCR™ System (Bio-Rad). The reaction mix was prepared in 96-well PCR plates and included 300–900 nM

(14) Targeted BDNF upregulation via upstream open reading frame disruptionMolecular TherapyMarch 4, 2026Ning Feng, Thomas Goedert, Nenad Svrzikapa, Dongnan Yan, Hans J. Friedrichsen, Britt Hanson, Alicia Ljungdahl, Ruxandra Dafinca, Kevin Talbot, Stephan J. Sanders, et al.between these steps was set to 2°C per second. After thermal cycling, the plate was analyzed using a QX600 droplet reader (Bio-Rad) according to the manufacturer’s instructions. Base editing Base editing guide

(15) Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clonesNatureFebruary 24, 2026Isabella A. T. M. Ferreira, Alberto Herrera, Tan Thinh Huynh, Emily Stone, Noemi L. Linden, Cristian Ovies, Yanqin Ren, Cintia Bittar, Virender K. Pal, Ethan Naing, et al.10 min; 45 cycles of (94 °C for 30 s, 59 °C for 1 min) and 98 °C for 10 min, then analysed with the QX600 Droplet Reader (Bio-Rad) using QuantaSoft software (v2.1; Bio-Rad). ARC isolation Limiting dilution

(16) Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profilingNature CommunicationsFebruary 20, 2026Rachel Scheck, Mark Melzer, Gregory Gladkov, Louise Leyre, Adam R. Ward, Daniel B. Reeves, Naomi Perkins, T. Thinh Huynh, Deborah K. McMahon, Ronald J. Bosch, et al.°C per cycle) and a final step 10 min at 98 °C before incubation at 4 °C. Droplets were read on the QX600 Droplet Reader (Bio-Rad). IPDA and parallel RPP30 assays for shearing correction and calculation of

(17) Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantationNatureFebruary 19, 2026Christian Gaebler, Samad Kor, Kristina Allers, Michela Perotti, David Mwangi, Karolin Meixenberger, Kirsten Hanke, Timo Trenkner, Tom Kraus, Yeqin Sha, et al.55 °C per cycle) and a final step 10 min at 98 °C before incubation at 4 °C. Droplets were read on a QX600 Droplet Reader (Bio-Rad). The following day, Parallel RPP30 assays were used to correct for DNA shearing

(18) Pathogen nucleic acids data in wastewater solids from 147 treatment plants in the United States: 2024-2025Data in BriefJanuary 27, 2026Alexandria B. Boehm, Marlene K. Wolfe, Amanda L. Bidwell, Alessandro Zulli, Bradley J. White, Bridgette Shelden, Dorothea Duongthermocycler. Cycling conditions are provided in Boehm et al. [2] Droplets were analyzed using the QX200 or QX600 Droplet Reader (Bio-Rad). Liquid transfers were performed using the Agilent Bravo (Agilent Technologies). Human

(19) MRGPRX2-expressing mast cells are increased in the GI tract of individuals with active inflammatory bowel disease and hereditary α-tryptasemiaFrontiers in AllergyJanuary 21, 2026Michelle Galeas-Pena, Jonathan J. Lyons, Dhana Llivichuzhca-Loja, Steve Everman, Ghina Yaghi, Katelyn White, Sangita Sutradhar, Tanya O. Robinson, Anna H. Owings, Neha S. Dhaliwal, et al.followed manufacturer's instructions. The assay was run in a BioRad automated droplet generator and BioRad QX600 droplet digital PCR system with BioRAD ddPCR reagents at the manufacturer recommended concentrations. Results were analyzed with

(20) Murine Neutrophil Chemotaxis Following Burn Injury with Poloxamer 188 Treatment in a Microfluidic PlatformbioRxivJanuary 10, 2026Hossein Razmi Bagtash, Nagham Alatrash, Udaya Sree Datla, Bhaskar Vundurthy, Shuai Shao, Roopa Koduri, Mecca Islam, Kevin Mutore, Emma Salari, Renqing Wu, et al.template for downstream digital droplet PCR (ddPCR) analysis. The ddPCR assay was performed using a QX600 ddPCR system (Bio-Rad), and data were analyzed with QX Manager 2.1 Standard Software. FPR1 and BLT1

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6/10/2026Great results when optimized, optimization takes awhile Elisebeth TorrettiMy lab uses the QX600 system for assessing gene copy number in human cells. We run a wide variety of sample types, but predominantly human iPSC DNA or cDNA.