RPTEC/TERT1 from ATCC

Product Specs
ItemRPTEC/TERT1
CompanyATCC
Price $8,670.00Supplier Page View Company Product Page
Catalog NumberCRL-4031
ApplicationsThese cells are proposed to be a valuable model system not only for cell biology, but also toxicology, drug screening, biogerontology and tissue engineering
TypeCell Biology
SpeciesHomo sapiens
Volume1.0 mL
Tissuekidney, Cortex:Epithelium:Proximal tubule
Cell LineRPTEC/TERT1
Tissue (standardized)Kidney
Cell Typeepithelial cell
Ageadult

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ATCC

10801 University Boulevard

Manassas, Virginia 20110-2209

United States

Phone: (703) 365-2700
Fax: (703) 365-2701

Company Profile

Website: http://www.atcc.org

(1) NTN1 regulates autophagy through the MAP1B/DAPK1 axis to ameliorate acute kidney injury in vitroOpen Med (Wars)May 19, 2026Meng Zhang, Heyu Tian, Jin Lin, Xi Wu, Deyuan ZhiCell culture Renal tubular epithelial cell line HK-2 (AW-CELLS-H0142, Anweisci, China), and RPTEC/TERT1 cells (CRL-4031, ATCC, Virginia, MA, USA) were placed in Minimum Essential Medium (MEM, BC-M-019, Sbjbio, China) enriched

(2) Genome instability triggers intercellular DNA transfer between human cellsCellMay 19, 2026Elizabeth G. Maurais, Alice Mazzagatti, Yu-Fen Lin, Maria Narozna, Qing Hu, Rashmi Dahiya, Derek Santiago-Ferrer, Conor P. Herlihy, Mary Krebs, Nikoleta Pateraki, et al.study,N/A RPE-1 + H2B-GFP + CAAX-Halo,This study,N/A RPE-1 + dCas9-SunTag,This study,N/A RPTEC,ATCC,CRL-4031 RPTEC CENPA−/− + mAID-GFP-CENP-A,This study,N/A RPTEC CENPA−/− + mAID-GFP-CENP-A + CENP-A mutant,This

(3) A VPS33B CRISPR knockout study: In vitro evidence of an adhesion defectPLoS OneFebruary 13, 2026Maria Caluianu, Kimberley A. Owenadult male primary proximal tubular cells with the human TERT-1 gene [14]. RPTEC-TERT1 cells (ATCC, #CRL-4031™) were cultured in DMEM:F12 Medium (ATCC® 30–2006™), supplemented with hTERT RPTEC Growth Kit (ATCC®

(4) An in vitro-in silico workflow for predicting renal clearance of environmental chemicals and drugsToxicologyJanuary 1, 2026Courtney Sakolish, Hsing-Chieh Lin, Haley L. Moyer, Lucie C. Ford, Charles H. Christen, Barbara A. Wetmore, Michael J. DeVito, Philip Hewitt, Stephen S. Ferguson, Farah Raad, et al.(hTERT-RPTEC) and its OAT1 transporter-overexpressing variant (hTERT-RPTEC-OAT1) were purchased from ATCC (#CRL-4031, #CRL-4031-OAT1; Manassas, VA). These cells were cultured as recommended by the vendor in DMEM/F12 (#30–2006,

(5) Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney diseaseScience AdvancesNovember 28, 2025Manuel Rogg, Lisa Weißer, Jasmin I. Maier, August Sigle, Martin Helmstädter, Marlene Stigler, Alena Sammarco, Katja Gräwe, Grigor Andreev, Charlotte Kark, et al.Medicine IV, Medical Centre, University of Freiburg, Freiburg, Germany) (71). Human RPTECs (RPTEC/TERT1, CRL-4031, ATCC) were used as model of proximal tubule cells. Cells were cultured in Dulbecco’s modified Eagle’s medium (DMEM

(6) Impact of C-Terminal PKC Phosphorylation on TRPC6 Current KineticsInternational Journal of Molecular SciencesNovember 27, 2025Maximilian Keck, Sebastian Pöll, Hannah Schmelzer, Tabea Kressmann, Christian Hermann, Michael Mederos y Schnitzler, Ursula Storchhuman renal proximal tubule epithelial (RPTEC/TERT1) cells (from ATCC, Manassas, VA, USA; Cat. No. CRL-4031). 4.3. Materials Poly-L-Lysine (Cat. No. P-1524), Bovine serum albumin (BSA; Cat. No. A7030), Bisindolylmaleimide I

(7) Distinct strategies of epithelial cell barrier disruption by Leptospira interrogans isolated from human patients in Okinawa, JapanPLOS Neglected Tropical DiseasesNovember 4, 2025Tetsuya Kakita, Claudia Toma, Isabel Sebastián, Hunter Barbee, Tetsu Yamashirodays with agitation at 30°C. 2.2 Cell culture RPTEC/TERT1 (American Type Culture Collection, ATCC CRL-4031) cells, human RPTECs immortalized by human Telomerase Reverse Transcriptase, were grown in Dulbecco’s

(8) Regulation of Klotho Production by Mineralocorticoid Receptor Signaling in Renal Cell LinesBiomoleculesOctober 25, 2025Elena Kohm, Martina Feger, Michael Föllerμg/mL streptomycin. hTERT-immortalized primary renal proximal tubule epithelial cells (RPTEC/TERT1; CRL-4031, ATCC) were cultured under standard cell culture conditions in DMEM/F-12 with 2.5 mM L-glutamine and

(9) Rational Design of Non-Toxic Multidrug Combinations Demonstrates Durable and Hypoxia-Enhanced Efficacy Against Renal Cell CarcinomaPharmaceuticsSeptember 27, 2025Valentin Mieville, Jakub Gubala, Mathis Fiault, Marie Ota, Seungsu Han, Muriel Urwyler, Daniel Benamran, Jean-Christophe Tille, Massimo Valerio, Patrycja Nowak-SliwinskaUSA, 41965-039), supplemented with 10% FBS and 1% penicillin/streptomycin. RPTEC (TERT1) cells (ATCC, CRL-4031) were cultivated in complete Renal Epithelial Cell Growth medium 2 (PromoCell®, C-26030) supplemented

(10) Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2-MyD88-NF-κB Signalling in NK CellsJ Extracell VesiclesJuly 17, 2025Ying Gong, Lingyue Jin, Lina Duan, Jie Xiao, Yao Li, HongXia Wang, Haifang Wang, Wanying Lin, Yi Zhang, Xiufeng Gan, et al.CST) antibodies were used for immunofluorescence staining. 2.3 Cell Culture RPTEC/TERT1 cells (Cat: CRL‐4031) and HK‐2 cells (Cat: CRL‐2190) were obtained from ATCC. RPTEC/TERT1 cells were cultured in DMEM:F12

(11) Evaluating Ion Mobility Data Acquisition, Calibration, and Processing for Small Molecules: A Cross-Platform Assessment of Drift Tube and Traveling Wave MethodologiesJournal of the American Society for Mass SpectrometryJuly 2, 2025James N. Dodds, Lucie C. Ford, Jack P. Ryan, Amie M. Solosky, Ivan Rusyn, Erin S. Bakerease of data extraction. Human renal proximal tubule epithelial cells (RPTECs), parent line (cat. no. CRL-4031) and OAT1-overexpressing variant (cat. no. CRL04031-OAT1) were purchased from ATCC (Manassas, VA). Cell culture medium

(12) Exploring the prognostic role and expression patterns of FAM3A family genes in kidney renal clear cell carcinomaSci RepJuly 1, 2025Shoaib Muhammad, Pengyu Yan, Huifang Wang, Ahmad Mahmood, Syed Shah Zaman Haider Naqvi, Muhammad Zaeem, Chun LiuCRL-2190™, and the RPTEC/TERT1 and RPTEC/TERT2 lines were also sourced from ATCC with catalog numbers CRL-4031™ and CRL-4032™. The HREC cell line was available from ScienCell Research Laboratories under catalog

(13) Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacityNat CommunJuly 1, 2025Victoria Gonzalez, Briallen Lobb, Jacob Côté, Arkadeb Bhuinya, Adriana G. Tubb, Stephen S. Nuthalapati, Akarin Asavajaru, Yan Zhou, Vikram Misra, Darryl Falzarano, et al.renal epithelial cell line isolated from the proximal tubule of a male patient (RPTEC-hTERT; ATCC, #CRL-4031) were grown in DMEM:F-12 media (ATCC; #30-2006) supplemented with the hTERT growth kit (ATCC; #ACS-4007).

(14) Protocol to develop a proximal tubule-on-chip model based on hiPSC-derived kidney organoids for functional analysis of renal transportersSTAR ProtocolsJune 20, 2025Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawalines ,, 4A6 (4A6C3-10),Toyohara et al.9,N/A CRL 1502.3,Takasato et al.6,N/A RPTEC/TERT1,ATCC,CAT. # CRL-4031 ,, Software and algorithms,Software and algorithms,Software and algorithms ,, ImageJ 1.51u,Schneider

(15) Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotypeNat CommunMay 22, 2025Maximilian Reck, David P. Baird, Stefan Veizades, Callum Sutherland, Rachel M. B. Bell, Heeyoun Hur, Carolynn Cairns, Piotr P. Janas, Ross Campbell, Andy Nam, et al.the fibrotic niche. Cell culture Primary renal proximal tubule epithelial cells (RPTEC/TERT1, ATCC CRL-4031) were cultured at 37 °C in a 5% CO2 incubator using custom medium containing 25 ng/ml hydrocortisone

(16) Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironmentiScienceApril 18, 2025Maximilian Wess, Manuel Rogg, Constance Gueib-Picard, Annika Merz, Anna L. Kössinger, Tobias Feilen, Grigor Andreev, Martin Werner, Ian J. Frew, Markus Grabbert, et al.with VHL re-expression) as well as human renal proximal tubule epithelial cells (RPTEC/TERT1, ATCC, CRL-4031, male donor) were used and obtained as recently described.78 A498, 786-O and hRPETC cell lines were

(17) Comparative Analysis of Proximal Tubule Cell Sources for In Vitro Studies of Renal Proximal Tubule ToxicityBiomedicinesFebruary 24, 2025Courtney Sakolish, Han-Hsuan D. Tsai, Hsing-Chieh Lin, Piyush Bajaj, Remi Villenave, Stephen S. Ferguson, Jason P. Stanko, Richard A. Becker, Philip Hewitt, Weihsueh A. Chiu, et al.heat-inactivated FBS (#16140071, Gibco). TERT1-parent and TERT1-OAT1 cells were obtained from ATCC (#CRL-4031, CRL-4031-OAT1; Manassas, VA, USA). These cells were cultured in DMEM:F12 (#30-2006; ATCC) supplemented

(18) Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscapeeLifeFebruary 17, 2025Cook AL, Sur S, Dobbyn L, Watson E, Cohen JD, Ptak B, Lee BS, Paul S, Hsiue E, Popoli M, et al.2022",N/A, Cell Line (Human),RPE1 TP53 224,"Cook et al., 2022",N/A, Cell Line (Human),RPTec,ATCC,"Cat #CRL-4031,RRID:CVCL_K278", Cell Line (Human),RPTec STAG2 3,"Cook et al., 2022",N/A, Cell Line (Human),RPTec

(19) BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinomaNature communicationsFebruary 11, 2025Liao C, Hu L, Jia L, Zhou J, Wang T, Kim K, Zhong H, Yao H, Dong L, Guo L, et al.gift from Dr. W. Kimryn Rathmell from Vanderbilt University. hTERT immortalized RPTEC cells (ATCC, CRL-4031) were a gift from Dr. Peter Ly from UT Southwestern. SV40 Large T antigen transformed RPTEC cells were

(20) Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamicsSci RepJanuary 20, 2025Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François-Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meomethods Cell culture RPTEC/TERT1 were obtained from American Type Culture Collection (ATCC) (ATCC, reference: CRL-4031), and cultured in Dulbecco’s modified Eagle’s medium with Ham’s F-12 nutrient mix (DMEM: F12) (ATCC,

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RPTEC/TERT1 from ATCC

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