TGF-beta 1 Protein 240-B-002 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTGF-beta 1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $351.00Supplier Page View Company Product Page
Catalog Number240-B-002
SpeciesHuman
Size2 ug (also 10 ug)
Molecule NameTGF-beta 1
Source/Expression SystemCHO-derived Recombinant Human TGF-beta 1 Protein
NCBI Full Gene Nametransforming growth factor beta 1
NCBI Gene AliasesTGF-beta1, TGFB, DPD1, TGFbeta, CED, IBDIMDE, LAP
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 12 kDa, reducing conditions 24 kDa, non-reducing conditions
Theoretical: 12.8 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 2 ug (also 10 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous PopulationsbioRxivApril 9, 2026Hyuntae Jeong, Jiwon Kim, Jea-Yun Sim, Susan E. Leggett, Ian Y. Wong(Invitrogen No. 15070–063). EMT was induced in MCF-10A cells using 1 ng/mL or 5 ng/mL TGF-β1 (R&D Systems, 240-B002) in growth media. Cells were cultured for 7 days in T25 tissue culture flasks (Genesee Scientific).

(2) Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndromeJCI InsightMarch 23, 2026Charmi Dedhia, Valentina Villani, Xiaogang Hou, Paolo Neviani, Geremy Clair, Mohammadreza Kasravi, Cristina Grange, Paolo Cravedi, Paola Aguiari, Velia Alcala, et al.VEGF (Thermo Fisher Scientific, Phc9394; 400 ng/mL, 3 days), mesangial cells to TGF-β (R&D Systems, 240-B-002; 1 mg/mL, 3 days), and podocytes to puromycin (Sigma-Aldrich, SBR00017; 50 μg/mL, 5 days). To reduce

(3) MRCKα Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular CellsCellsMarch 2, 2026Veroni S. Sri Theivakadadcham, Qinghong Dan, Brian Wu, Shruthi Venugopal, Vida Maksimoska, Aysegul Yucel-Polat, Andras Kapus, Katalin SzásziMedChem Express (Monmouth Junction, NJ, USA, Cat#HY-P7118) or R&D Systems (Minneapolis, MN, USA, Cat#240-B-002). Rhosin Hydrochloride (Cat#5003) was from Tocris Bioscience (Biotechne), Abingdon, UK. The following

(4) Suppression of interferon signaling via small molecule modulation of TFAMeLifeFebruary 6, 2026Dionisia P Sideris, Hsuan Lee, Lyndsay Olson, Kalyan Nallaparaju, Keiichiro Okuyama, Jeffrey Ciavarri, Robert Lafyatis, Mads B Larsen, Bo Lin, Irene Alfaras, et al.for 6 days in presence of IL-2 (100 U/mL; Peprotech, Ct# 200-02) and TGF-b (5 ng/mL; Biotechne Cat# 240-B-002) in the presence of Dynabeads Human T-activator CD3/28 (Life Technologies, Cat# 11132D) at a ratio of

(5) Suppression of interferon signaling via small-molecule modulation of TFAMElifeFebruary 6, 2026Dionisia Sideris, Husan Lee, Lyndsay Olson, Kalyan Nallaparaju, Keiichiro Okuyama, Jeffrey Ciavarri, Robert Lafyatis, Mads Larsen, Bo Lin, Irene Alfaras, et al.for 6 days in presence of IL-2 (100 U/mL; Peprotech, Ct# 200-02) and TGF-b (5 ng/mL; Biotechne Cat# 240-B-002) in the presence of Dynabeads Human T-activator CD3/28 (Life Technologies, Cat# 11132D) at a ratio of

(6) TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNAAdvanced ScienceFebruary 3, 2026Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, et al.is provided in the Supporting Information. 4.1 Reagents Reagents were purchased as follows: TGFβ1 (240‐B‐002, R&D Systems, Minneapolis, MN, USA); SB525334 (S1476, Selleckchem, Houston, TX, USA); actinomycin‐D

(7) Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast–Myofibroblast Transition and Renal FibrosisResearch (Wash D C)January 29, 2026Fang Chen, Lijun Zhang, Weiying Liu, Bingbing Zhang, Shuren Wang, Zhengdong Zhou, Wei Wang, Jiansong Shen, Yijun Deng, Wangsen Cao(Gibco, USA) in a humidified atmosphere of 5% CO2 incubator at 37 °C. Cells were treated with TGFβ (240-B-002, R&D Systems, USA), AAI, and the HDAC3-selective inhibitor RG as indicated. RASAL1 knockdown by RNA

(8) The E3 ligases Itch and WWP2 regulate autoimmune neuroinflammation by controlling TH2 to TH17 cell conversion via interleukin-4-STAT5 axis in miceNature CommunicationsJanuary 23, 2026Mei Zhao, Chao Zhang, Xin Zhang, Qingdian Mu, Qian Li, Yun-Cai Liuanti-mouse IFN-γ (10 µg/ml). TH17 cells were generated using a combination of human TGF-β (R&D Systems, #240-B-002, 1 ng/ml), mouse interleukin 6 (mIL-6) (Pepro Tech, #216-16, 20 ng/ml), and anti-mouse IFN-γ (10 µg/ml).

(9) MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentationCommunications BiologyJanuary 22, 2026Mayukha Bathini, Diana Bocaniciu, Fraser D. Johnson, Rick C. P. de Jong, Fengchao Yu, Vincenzo Davide Aloi, Marije C. Kuiken, Janniek R. Mors, Lisanne Giebel, Julien Champagne, et al.°C. For the TGFβ stimulation experiment, the cells were treated overnight with 5 ng/mL of human TGFβ (240-B-002, Bio-Techne) for 18 h. For interferon stimulation, the cells were treated with a range of IFNy (PHC4031,

(10) Versican expression from lung fibroblasts suppresses pulmonary fibrosisNature CommunicationsJanuary 21, 2026Paraskevi Kanellopoulou, Ilianna Barbayianni, Dionysios Fanidis, Martina Samiotaki, Eleni Katsiouli, Dimitris Nastos, Stefanos Smyrniotis, Maria Shira, Apostolos Galaris, Vagelis Rinotas, et al.For stimulation experiments, cells were treated with 10 ng/mL recombinant human TGF-β1 (R&D Systems, 240-B-002) for 24 h, while control samples received vehicle (7.5% BSA in H₂O). For pharmacological assays, cells

(11) Secreted exosomes induce filopodia formationElifeJanuary 14, 2026Caitlin McAtee, Mikin R Patel, Daisuke Hoshino, Bong Hwan Sung, Ariana K von Lersner, Mingjian Shi, Nan Hyung Hong, Anna Young, Evan Krystofiak, Andries Zijlstra, et al.phalloidin. For TGF-β1 treatment, desired concentration of recombinant human TGF-β1 (R&D Systems Cat #240-B-002; reconstituted in sterile 4 mM HCl +0.1% BSA) was diluted in OptiMEM, added to cells at time of seeding,

(12) Uridine-Cytidine Kinase 2 (UCK2)/Uridine-Cytidine Kinase Like 1 (UCKL1) complex exacerbates the differentiation of myocardial fibroblasts via TRIM21/Smurf2/Smad3 pathway after myocardial infarctionMol BiomedDecember 29, 2025Xiao Zhou, Yu Zhang, Hao Wang, Zhen Qi, Ziyi Gu, Jun Cui, Zhenlei Hu, Yongyi Wanglow serum medium and then treated with 10 ng/ml recombinant human TGF-β (R&D Systems, catalogue no. 240-B-002) for the specified durations. Cell viability assay Cell viability was quantitatively assessed using

(13) Regulation of corneal stromal cell behavior by modulating curvature using a hydraulically-controlled organ chip arrayNature CommunicationsNovember 12, 2025Minju Kim, Kanghoon Choi, David Križaj, Jungkyu Kimgenerated by culturing HCKs in DMEM/F12 with 10% FBS and 10 ng/mL transforming growth factor-β (TGF-β; 240-B-002, R&D Systems). All cell types were expanded on flat substrates for three days, validated, and then seeded

(14) T H 17 cells converted into exT H 17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritisScience ImmunologyNovember 7, 2025Martina Zoccheddu, Kensuke Suga, Amara Seng, Mattias N. D. Svensson, Paramita Dutta, Sanaz Panahandeh, Hadijat-Kubura Moradeke Makinde, Myungja Ro, Yizhou Wang, Hyobin Kim, et al.conditions - T cells media with: 50 ng/mL IL-6 (cat# 406-ML-005 R&D Systems), 5 ng/mL rhTgfb (cat# 240-B-002 R&D Systems), 1 ug/mL LEAF anti-CD28 (clone 37.51 cat# 102115 Biolegend), 10 ug/mL Ultra-LEAF anti-IL-4

(15) HSF2 drives breast cancer progression by acting as a stage-specific switch between proliferation and invasionScience AdvancesSeptember 5, 2025Jenny C. Pessa, Oona Paavolainen, Hendrik S. E. Hästbacka, Mikael C. Puustinen, Alejandro J. Da Silva, Sandra Pihlström, Silvia Gramolelli, Pia Boström, Pauliina Hartiala, Emilia Peuhu, et al.were treated with assay medium supplemented with TGF-β1 (10 ng/ml; hereafter referred to as TGF-β, 240-B-002, R&D Systems) for 24 or 72 hours (35). For the longer treatment, the medium was replaced after 48 hours.

(16) Integration of phospho-signaling and transcriptomics in single cells reveals distinct Th17 cell fatesCell reportsAugust 26, 2025Fortmann SD, Chadha AS, Frey BF, Elahi A, Hanumanthu VS, Liu S, Goldsborough A, Ferrell PB Jr, Grant MB, Weaver CT, et al.

(17) Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiationCardiovascular ResearchAugust 14, 2025Anuradha Kaistha, Sebnem Oc, Abel Martin Garrido, James C K Taylor, Maria Imaz, Matthew D Worssam, Anna Uryga, Mandy Grootaert, Kirsty Foote, Alison Finigan, et al.then serum-starved for 4–6 h. Cells were then treated with recombinant TGFb1 (10 ng/mL, R&D Systems 240-B-002) or vehicle for 1, 24, or 48 h in DMEM containing 0.5% serum or left in 2.5% serum medium overnight

(18) Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signalingScientific reportsAugust 2, 2025Baba Y, Maezawa Y, Kondo N, Minamizuka T, Udagawa H, Ide S, Ide K, Teramoto N, Yamaguchi A, Kaneko H, et al.

(19) Estradiol Downregulates MicroRNA-193a to Mediate Its Angiogenic ActionsCellsJuly 23, 2025Rigassi L, Popa MA, Stiller R, Leeners B, Rosselli M, Dubey RK.

(20) MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentationbioRxivJuly 23, 2025Mayukha Bathini, Diana Bocaniciu, Fraser D. Johnson, Rick C.P. de Jong, Fengchao Yu, Vincenzo Davide Aloi, Marije C. Kuiken, Janniek R. Mors, Lisanne Giebel, Julien Champagne, et al.°C. For the TGFβ stimulation experiment, the cells were treated overnight with 5 ng/mL of human TGFβ (240-B-002, Bio-Techne) for 18 hours. For interferon stimulation, the cells were treated with a range of IFNy (PHC4031,

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1/18/2023Good TGF-b1 Protein (240-B) Liyong Z.To induce EMT for BT20 cells, 10 ng/ml TGF-b1 was administered for incubation of 72 h. The cells were collected for fractionation using NE-PER Nuclear and Cytoplasmic Extraction Reagents (78833). The ... Read Review

Recombinant Human TGF-beta 1 Protein

TGF-beta 1 Protein

TGF-beta 1 Protein

TGF-beta 1 Protein

TGF-beta 1 Protein

TGF-beta 1 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (1043)

Reviews

TGF-beta 1 Protein from R&D Systems, a Bio-Techne Brand

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