Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate ES001 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $562.00Supplier Page View Company Product Page
Catalog NumberES001
Size1 mg
ApplicationsBioactivity, Binding Activity
Molecular Weight1093 Da
SpeciesMulti-Species
Molecule NameProtease Substrates
ImmunogenMca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(21) Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, ^99mTc-labeling, and EvaluationScientific reportsAugust 3, 2018Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, et al.

(22) Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP CleavageJournal of molecular biologyMay 25, 2018Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, John V.

(23) Factor X activating Atractaspis snake venoms and the relative coagulotoxicity neutralising efficacy of African antivenomsToxicology LettersMay 15, 2018Brice Oulion, James S. Dobson, Christina N. Zdenek, Kevin Arbuckle, Callum Lister, Francisco C.P. Coimbra, Bianca op den Brouw, Jordan Debono, Aymeric Rogalski, Aude Violette, et al.substrate only. For testing on RDES substrates (Fluorogenic Peptide Substrate, R & D systems Cat#s ES001, ES002, ES005 AND ES0011, Minneapolis, Minnesota), 10ul of 0.01 µg/µl venom stock was plated in triplicate

(24) Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in EpilepsyThe Journal of neuroscience : the official journal of the Society for NeuroscienceMay 2, 2018Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B.brain capillaries was measured with a substrate activity assay using Mca-PLGLDpa-AR-NH2 fluorogenic MMP substrate (#ES001, R&D Systems). Brain capillaries were lysed in CelLytic M (Sigma-Aldrich) using a Polytron 2500E homogenizer

(25) Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injuryJournal of neuroinflammationMarch 20, 2018Remacle AG, Hullugundi SK, Dolkas J, Angert M, Chernov AV, Strongin AY, Shubayev VI.

(26) The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteasesPloS oneJanuary 1, 2018Sylte I, Dawadi R, Malla N, von Hofsten S, Nguyen TM, Solli AI, Berg E, Adekoya OA, Svineng G, Winberg JO.Auerolysin was from BioCentrum Ltd (Kraków, Poland). The chromogenic substrates Mca-PLGLDpaAR-NH2 (ES001) and Mca-RPPGFSAFK(Dnp)-OH (ES005) were from R&D Systems, Inc (Minneapolis, MN, USA). Azasugar-based

(27) Programmed biomolecule delivery to enable and direct cell migration for connective tissue repairNature communicationsNovember 24, 2017Qu F, Holloway JL, Esterhai JL, Burdick JA, Mauck RL.

(28) Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus)ToxinsMay 19, 2017Debono J, Dobson J, Casewell NR, Romilio A, Li B, Kurniawan N, Mardon K, Weisbecker V, Nouwens A, Kwok HF, et al.enzyme buffer, 150 mM NaCl, and 50 mM Tri-HCl (pH 7.3), Fluorogenic Peptide Substrate, R&D systems, Cat#ES001 & ES011, Minneapolis, MI, USA). Fluorescence was monitored by a Fluoroskan Ascent™ (Thermo Scientific,

(29) Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivoScientific reportsDecember 16, 2016Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, Yaron A, Milla ME, Sagi I.

(30) Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper VenomsToxins (Basel)July 8, 2016Jordan Debono et al.adding quenched fluorescent substrate (10 µM final; Fluorogenic Peptide Substrate, R & D systems, Cat#ES001, Minneapolis, Minnesota). Fluorescence was monitored (excitation at 320 nm and emission at 405 nm) over 100

(31) Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injuryAngiogenesisApril 1, 2016Gallardo-Vara E, Blanco FJ, Roqué M, Friedman SL, Suzuki T, Botella LM, Bernabeu C.activity Metalloproteinase activity of HUVECs was determined using the fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (ES001; R&D Systems). HUVEC monolayers, at control conditions and at different times after wounding, were washed

(32) Insulin-Like Growth Factor I (IGF-I) Expressed from an AAV1 Vector Leads to a Complete Reversion of Liver Cirrhosis in RatsPloS oneJanuary 1, 2016Sobrevals L, Enguita M, Quiroga J, Prieto J, Fortes P.

(33) Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2BMC cancerDecember 16, 2015Pei S, Yang X, Wang H, Zhang H, Zhou B, Zhang D, Lin D.902MP,R&D system,Inc. U.S.A) and 50 μL of 20 μM Substrate (MCAProLeuGlyLeuDPAAlaArgNH) (Catalog#ES001,Catalog # 911MP,R&D system, Inc.U.S.A) into Black Maxisorp Plate(Nunc, Catalog # 475515, Dermar-k)

(34) High-grade serous ovarian cancer cell lines exhibit heterogeneous responses to growth factor stimulationCancer cell internationalJanuary 1, 2015Bourgeois DL, Kabarowski KA, Porubsky VL, Kreeger PK.

(35) Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseasesGutOctober 1, 2014Urribarri AD, Munoz-Garrido P, Perugorria MJ, Erice O, Merino-Azpitarte M, Arbelaiz A, Lozano E, Hijona E, Jiménez-Agüero R, Fernandez-Barrena MG, et al.cultures from humans and rats using an assay based on cleavage of the fluorogenic synthetic peptide ES001 (R&D Systems Minneapolis, Minnesota, USA). Details are described in the online supplementary materials

(36) Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cellsFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAugust 1, 2014Haage A, Schneider IC.throughout the experiments. 10µM of S-MMP (Mca-PLGL-Dpa-AR-NH2, R & D Systems, Minneapolis, MN, USA, ES001) or MT-MMP (McaPLA-C(OMeBz)-WAR(Dpa)-NH2, Calbiochem, Billerica, MA, USA, 444528) quenched fluorescent

(37) Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs and invasionBiochemical and biophysical research communicationsJuly 18, 2014Haage A, Nam DH, Ge X, Schneider IC.DX-2400 Fab using quenched fluorescent cleavage peptides S-MMP (Mca-PLGLDpa-AR-NH2, R & D Systems, ES001) or MT-MMP (Mca-PLA-C(OMeBz)-WAR(Dpa)-NH2, Calbiochem, 444528) as the substrate. Cell Culture, ECM Conditions

(38) Soft matrix is a natural stimulator for cellular invasivenessMolecular biology of the cellFebruary 1, 2014Gu Z, Liu F, Tonkova EA, Lee SY, Tschumperlin DJ, Brenner MB.in cell culture conditioned media was determined using the Mca-PLGL-Dpa-AR-NH2 fluorogenic peptide substrate (ES001; R&D Systems) according to manufacturer's instructions. A 75-μl amount of conditioned medium was transferred

(39) Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smokeThe American journal of pathologyMay 1, 2013Li CJ, Liu Y, Chen Y, Yu D, Williams KJ, Liu ML.

(40) Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincinsThe Journal of biological chemistryAugust 3, 2012Devel L, Beau F, Amoura M, Vera L, Cassar-Lajeunesse E, Garcia S, Czarny B, Stura EA, Dive V.

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Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate from R&D Systems, a Bio-Techne Brand

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