PLEKHG5 ELISA kits are immunoassay tools for the measurement of the protein pleckstrin homology and RhoGEF domain containing G5, which is encoded by the PLEKHG5 gene in humans. Functionally, this protein is known to function as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). The canonical protein structure is reported to have an amino acid sequence of 1006 residues and a mass of 111.2 kDa. It is known to be localized in the cell membrane, cytoplasmic vesicles, and cytoplasm and is reported to be highly expressed in the the peripheral nervous system and brain. As many as 4 protein isoforms have been reported. The PLEKHG5 gene has been associated with the disease, Distal spinal muscular atrophy. Other alias names for this target include PH domain-containing family G member 5, guanine nucleotide exchange factor 720, novel PH domain-containing protein, and pleckstrin homology domain-containing family G member 5.
The detection range for different PLEKHG5 ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.