PXDN ELISA kits are immunoassay tools for the measurement of the protein peroxidasin, which is encoded by the PXDN gene in humans. Functionally, this protein is known to catalyze the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-linked collagen IV/COL4A1 NC1 hexamer. The canonical protein structure is reported to have an amino acid length of 1479 residues, a mass of 165.3 kDa, and is a member of the Peroxidase protein family. It is known to be localized in the ER, extracellular matrix, and is secreted and is noted to be expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. As many as 2 protein isoforms have been reported. The protein has been noted to be post-translationally N-glycosylated and cleaved. The PXDN gene has been associated with the disease, Anterior segment dysgenesis. Other alias names for this target include COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO, and ASGD7.
The detection range for different PXDN ELISA kits can vary, with some assays measuring target concentrations as low as 50 ng/L and as high as 100 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.