AIRE ELISA kits are immunoassay tools for the measurement of the protein autoimmune regulator, which is encoded by the AIRE gene in humans. Functionally, this protein is reported to be a transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA). The canonical protein structure is reported to have an amino acid sequence of 545 residues and a mass of 57.7 kDa. It is known to be localized in the nucleus and cytoplasm and is widely expressed across many tissue types. As many as 4 protein isoforms have been reported. The protein has been noted to be post-translationally phosphorylated. The AIRE gene has been associated with the disease, Autoimmune polyendocrine syndrome. Other alias names for this target include APECED, APS1, APSI, PGA1, autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, and AIRE1.
Some AIRE ELISA kits can detect targets at levels as low as 31.25 pg/mL and as high as 40 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.