The following SMAD Family Member 2 ELISA kits are useful research tools for the measurement of SMAD family member 2 in biological samples. In humans this protein is encoded by the SMAD2 gene. This protein is a known receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. The canonical protein structure is reported to have an amino acid length of 467 residues, a mass of 52.3 kDa, and is a member of the Dwarfin/SMAD protein family. Its subcellular location is known to be in the nucleus and cytoplasm. In addition, it is notably expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. As many as 2 protein isoforms have been reported. In certain instances, it is also post-translationally ubiquitinated, acetylated and phosphorylated. The gene encoding this protein has been associated with the disease, Congenital heart defects. This protein may also be known as JV18, JV18-1, LDS6, MADH2, MADR2, hMAD-2, hSMAD2, and CHTD8.
Some SMAD Family Member 2 ELISA kits can detect targets at levels as low as 10 ng/L and as high as 40 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.