HMGCS2 ELISA kits are immunoassay tools for the measurement of the protein 3-hydroxy-3-methylglutaryl-CoA synthase 2, which is encoded by the HMGCS2 gene in humans. Functionally, this protein is known to catalyze the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. The canonical protein structure is reported to have an amino acid length of 508 residues, a mass of 56.6 kDa, and is a member of the HMG-CoA synthase protein family. It is known to be localized in the mitochondria. As many as 3 protein isoforms have been reported. The HMGCS2 gene has been associated with the disease, 3-hydroxy-3-methylglutaryl-CoA synthase-2 deficiency. Other alias names for this target include 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial), 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial), HMG-CoA synthase, and hydroxymethylglutaryl-CoA synthase, mitochondrial.
Some HMGCS2 ELISA kits can detect targets at levels as low as 15.625 pg/mL and as high as 30 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.