MTHFD1 ELISA kits are immunoassay tools for the measurement of the protein methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, which is encoded by the MTHFD1 gene in humans. Functionally, this protein is reported to be a trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. The canonical protein structure is reported to have an amino acid length of 935 residues, a mass of 101.5 kDa, and is a member of the Tetrahydrofolate dehydrogenase/cyclohydrolase protein family; Formate--tetrahydrofolate ligase protein family. It is known to be localized in the cytoplasm and is ubiquitously expressed across many tissue types. The MTHFD1 gene has been associated with the disease, Neural tube defects. Other alias names for this target include MTHFC, MTHFD, C-1-tetrahydrofolate synthase, cytoplasmic, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase, and CIMAH.
There are MTHFD1 ELISA kits that can detect a target at concentrations as low as 78 pg/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.