The following cereblon ELISA kits are useful research tools for the measurement of cereblon in biological samples. In humans this protein is encoded by the CRBN gene. This protein is reported to be a substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. The canonical protein structure is reported to have an amino acid length of 442 residues, a mass of 50.5 kDa, and is a member of the CRBN protein family. Its subcellular location is known to be in the membrane, nucleus, and cytoplasm. In addition, it is widely expressed across many tissue types. As many as 2 protein isoforms have been reported. In certain instances, it is also post-translationally ubiquitinated. The gene encoding this protein has been associated with the disease, Intellectual developmental disorder. This protein may also be known as MRT2A, protein cereblon, protein x 0001, and MRT2.
There are cereblon ELISA kits that can detect a target at concentrations as low as 0.1 ng/mL and as high as 40 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.