SAMHD1 ELISA kits are immunoassay tools for the measurement of the protein SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1, which is encoded by the SAMHD1 gene in humans. Functionally, this protein is a reported protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. The canonical protein structure is reported to have an amino acid length of 626 residues, a mass of 72.2 kDa, and is a member of the SAMHD1 protein family. It is known to be localized in the nucleus and is found to be expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally ubiquitinated and phosphorylated. The SAMHD1 gene has been associated with the disease, Aicardi-Goutieres syndrome. Other alias names for this target include DCIP, HDDC1, MOP-5, SBBI88, hSAMHD1, and CHBL2.
The detection range for different SAMHD1 ELISA kits can vary, with some assays measuring target concentrations as low as 78 pg/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.