PSEN2 ELISA kits are immunoassay tools for the measurement of the protein presenilin 2, which is encoded by the PSEN2 gene in humans. Functionally, this protein is a suspected catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The canonical protein structure is reported to have an amino acid length of 448 residues, a mass of 50.1 kDa, and is a member of the Peptidase A22A protein family. It is known to be localized in the ER and golgi. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally cleaved and phosphorylated. The PSEN2 gene has been associated with the disease, Alzheimer disease. Other alias names for this target include AD4, CMD1V, PS2, STM2, AD3LP, AD5, Alzheimer disease 3-like, and AD3L.
The detection range for different PSEN2 ELISA kits can vary, with some assays measuring target concentrations as low as 1.25 pg/mL and as high as 50 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.