NOTCH2 ELISA kits are immunoassay tools for the measurement of the protein notch receptor 2, which is encoded by the NOTCH2 gene in humans. Functionally, this protein is known to function as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. The canonical protein structure is reported to have an amino acid length of 2471 residues, a mass of 265.4 kDa, and is a member of the NOTCH protein family. It is known to be localized in the cell membrane, nucleus, and cytoplasm and is reported to be expressed in the brain, heart, kidney, lung, skeletal muscle and liver. The protein has been noted to be post-translationally glycosylated, ubiquitinated, cleaved and phosphorylated. The NOTCH2 gene has been associated with the disease, Alagille syndrome. Other alias names for this target include HJCYS, hN2, neurogenic locus notch homolog protein 2, Notch homolog 2, and AGS2.
The detection range for different NOTCH2 ELISA kits can vary, with some assays measuring target concentrations as low as 0.14 ng/mL and as high as 100 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.