SMAD2 ELISA kits are immunoassay tools for the measurement of the protein SMAD family member 2, which is encoded by the SMAD2 gene in humans. Functionally, this protein is a known receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. The canonical protein structure is reported to have an amino acid length of 467 residues, a mass of 52.3 kDa, and is a member of the Dwarfin/SMAD protein family. It is known to be localized in the nucleus and cytoplasm and is notably expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. As many as 2 protein isoforms have been reported. The protein has been noted to be post-translationally ubiquitinated, acetylated and phosphorylated. The SMAD2 gene has been associated with the disease, Congenital heart defects. Other alias names for this target include JV18, JV18-1, LDS6, MADH2, MADR2, hMAD-2, hSMAD2, and CHTD8.
The detection range for different SMAD2 ELISA kits can vary, with some assays measuring target concentrations as low as 10 ng/L and as high as 40 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.