The PGRN ELISA kits listed below utilize specific antibodies for the plate-based assay of PGRN in various samples. PGRN is another term for the GRN gene, which encodes the protein, granulin precursor in humans. It has been reported that PGRN plays a role in the regulation of apoptosis, among other functions. Structurally, the GRN protein is 593 amino acid residues in length and 63.5 kilodaltons in mass. However, as many as 3 protein isoforms have been identified. Its subcellular localization is in the lysosomes and is secreted. This protein is known to be cleaved and glycosylated. Other names for this target antigen include CLN11, GEP, and GP88.
The detection range for different PGRN ELISA kits can vary, with some assays measuring target concentrations as low as 15.63 pg/mL and as high as 200 µg/mL. Click on the following ELISA kits for more detailed information, including target reactivity and assay sensitivity.