Prostaglandin J2 ELISA kits are designed for the specific detection of prostaglandin J2 in biological samples. Prostaglandin J2 is a compound that is metabolized in humans and can be detected in serum samples. It has the chemical formula C20H30O4. Prostaglandin J2 (PGJ2), an endogenous inflammatory product, is implicated in neurodegenerative disorders by inducing neuronal death and protein aggregation. The cyclopentenone prostaglandin disrupts the cytoskeleton in neuronal cells, leading to endoplasmic reticulum collapse and the formation of centrosomal aggregates containing ubiquitinated proteins and alpha-synuclein.
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1 Human Metabolome Database (HMDB) v5.0