IgE ELISA kits are assays designed to detect immunoglobulin E (IgE), a class of antibodies found only in mammals. Synthesized by plasma cells, IgE is a protein complex consisting of two heavy chains and two light chains. It occurs in the serum at lower levels than most other immunoglobulin types. IgE is involved in type 1 hypersensitive allergic reactions and mediation of immunity against parasitic helminth diseases. IgE can upregulate the expression of the FcεRI receptor, binding to it and allowing expression on inflammatory cells such as dendritic cells, mast cells, and basophils. Once the allergen binds to the IgE molecule, cross-linking of effector IgE triggers cellular signaling pathways that release chemical mediators. IgE is an important target in medication for asthma, sinusitis, and food allergies. IgE kits can be useful for allergy detection and the study of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE). Visit the supplier page to learn more, including details on detection, sensitivity, and origin.