Anti-Exportin 5 antibodies are used in the immunodetection of the protein encoded by the XPO5 gene. In humans, the canonical protein has a reported length of 1204 amino acid residues and a mass of 136.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is found to be expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. A member of the Exportin protein family, it is known to mediate the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Other names for this target antigen include ran-binding protein 21.