Anti-CD79A antibodies are used in the immunodetection of the protein CD79a molecule. In humans, the canonical protein has a reported length of 226 amino acid residues and a mass of 25 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the rectum, lymph node, colon, bone marrow, and appendix. CD79A is known to be required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Post-translational modifications have been described, including phosphorylation and glycosylation.
The CD79A marker can be used to identify B Cells, Large Intestine Lamina Propria Lymphocytes, Regulatory T Cells, Plasma Cells, and Naive B Cells.* Synonyms for this target antigen include IGAlpha, MB-1, MB1, B-cell antigen receptor complex-associated protein alpha chain, CD79a antigen (immunoglobulin-associated alpha), and IGA. CD79A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4