Anti-IRF8 antibodies are used in the immunodetection of the protein interferon regulatory factor 8. In humans, the canonical protein has a reported length of 426 amino acid residues and a mass of 48.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be highly expressed in the lymphoid tissues. A member of the IRF protein family, IRF8 is reported to be a transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)).
The IRF8 marker can be used to identify Myeloid Progenitors (MOP), Early T Lineage Precursor Cells, Thymic Plasmacytoid Dendritic Cells, and CD8?+ Thymic Conventional Dendritic Cells.* Synonyms for this target antigen include ICSBP, ICSBP1, IMD32A, IMD32B, interferon consensus sequence binding protein 1, and H-ICSBP. IRF8 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 100 citations in the literature describe the use of IRF8 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4