IRF-8 (D20D8) Rabbit mAb 5628S from Cell Signaling Technology

Product Specs
ItemIRF-8 (D20D8) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5628S
Quantity100 µl
ApplicationsW, W-S, IP, ChIP, ChIP-seq
ReactivityH, M
TargetIRF-8
IsotypeIgG
HostRabbit
NCBI Gene AliasesH-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, IRF-8
NCBI Full Gene Nameinterferon regulatory factor 8
CloneD20D8
Molecular Weight50
ClonalityMonoclonal
Research AreaImmunology and Inflammation

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Immunomodulatory supramolecular hydrogel for rheumatoid arthritis management via adenosine A2A receptor-mediated macrophage remodelingBioactive materialsApril 1, 2026Shi G, Liu X, Wei Y, Gao R, Gao X, Zhou Y, Chen C, Yang J, Wang W, Sun L, et al.of adenosine A2AR (sc-32261, Santa Cruz), IRF4 (#62834S, Cell Signaling Technology, MA, USA), IRF8 (#5628T, Cell Signaling Technology, MA, USA) and GAPDH (TA-08, ZSGB-BIO, Beijing, China). After incubating with

(2) Rhinovirus Infection Promotes Suppression of Sphingosine and Enhanced Bacterial Infection in Cystic Fibrosis AirwaysJournal of Biological ChemistryMarch 19, 2026Gregory C. Wilson, Simone Keitsch, Barbara Wilker, Matthias Soddemann, Markus Kamler, Erich Gulbins(ThermoFisherScientific, #37542) for 60 min, washed and incubated for 60 min with anti-IRF8 (Cell Signaling Clone D20D8, #5628), anti-phospho-Stat3 (Tyr705) (Cell Signaling, #9131) antibodies or anti-Stat3 antibodies (Cell Signaling,

(3) Dissection of innate-immune-ligand- and interferon-protein-mediated transcriptional responses in human THP1 cell statesCommun BiolFebruary 12, 2026Lodoe Lama, Pavel Morozov, Aitor Garzia, Thomas Tuschldetected by Western blotting using antibodies from Cell Signaling Technology, IRF1 8478S, IRF7 4920S, IRF8 5628S, IRF9 76684S, STAT1 9175S, pSTAT1-Y701 9167S, pIRF3-S386 37829S, pIRF3-S396 4947S, pTBK1-S172 5483S,

(4) CUSP06, a Novel CDH6-Targeted Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Multiple CDH6-Expressing Human Cancer ModelsPharmaceuticsAugust 13, 2025Wei Lu, Jing Shi, Wentao Zhang, Nicole Covino, Amy Penticoff, Robert Phillips, John Cogswell, Laurie Tatalick, Stephanie Pasas-Farmer, Jianjian Zhang, et al.Technology, Danvers, MA, USA, (CST) 2348), total Chk1 (CST, 2360), Phospho-H2AX (CST 9718), cleaved PARP (CST 5628), and β-actin (CST 3700). The secondary antibody (IR-Dye 800 CW Goat anti Rabbit IgG (H + L), LICOR)

(5) IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axisGenes & DiseasesMay 1, 2025Xinyue Li, Hong Zhang, Fan Yu, Shuting Xie, Tongyu Wang, Rong Zhang, Guangzhong Xu, Liang Wang, Yeping Huang, Cheng Hu(Thermo Fisher Scientific, USA) were used to acquire images. The antibodies including anti-IRF8 (1:1000; 5628S, Cell Signaling Technology, USA), anti-BMAL1 (1:1000; 14020S, Cell Signaling Technology), anti-PPARγ

(6) Bi-functional CpG-STAT3 decoy oligonucleotide triggers multilineage differentiation of acute myeloid leukemia in miceMolecular Therapy - Nucleic AcidsSeptember 10, 2024Dongfang Wang, Damian Kaniowski, Karol Jacek, Yu-Lin Su, Chunsong Yu, Jeremy Hall, Haiqing Li, Mingye Feng, Susanta Hui, Bożena Kaminska, et al.(Abcam: ab305429, ab122932), IRF8, mouse anti-rabbit immunoglobulin (Ig)G, and β-actin (Cell Signaling: 5628, 93702, 5125). For immunohistochemical staining, the formalin-fixed paraffin-embedded spleen sections

(7) SMARCA4 (BRG1) is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisionsCancer CellApril 8, 2024Qing Deng, Priya Lakra, Panhong Gou, Haopeng Yang, Cem Meydan, Matthew Teater, Christopher Chin, Wenchao Zhang, Tommy Dinh, Usama Hussein, et al.IRF-1 (D5E4) XP® Rabbit mAb,Cell Signaling Technology,Cat# 8478 IRF-8 (D20D8) Rabbit mAb,Cell Signaling Technology,Cat# 5628 BCL6 Polyclonal Antibody,Life Technologies,Cat# PA527390 PU.1 Antibody,Cell Signaling Technology,Cat#

(8) Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and miceNature communicationsMarch 26, 2024Luu LDW, Pandey A, Paramsothy S, Ngo C, Castaño-Rodríguez N, Liu C, Kamm MA, Borody TJ, Man SM, Kaakoush NO.#PA5105214), IRF4 (New England Biolabs, #4948S), IRF5 (Abcam, #ab33478), IRF8 (Cell Signaling Technology, #5628), Phospho-STAT1 (Cell Signaling Technology, #9167), STAT1 (Cell Signaling Technology, #14994), Phospho-STAT3

(9) Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritisiScienceOctober 20, 2023Tanya J. Lupancu, Kevin M.C. Lee, Mahtab Eivazitork, Cecil Hor, Andrew J. Fleetwood, Andrew D. Cook, Moshe Olshansky, Stephen J. Turner, Richard de Steiger, Keith Lim, et al.,Cell Signaling Technology,Cat#15106; RRID:AB_2798709 IRF-8 (D20D8) Rabbit,Cell Signaling Technology,Cat#5628; RRID:AB_10828231 β-Actin (AC-74) Mouse,Merck,Cat#A5316; RRID:AB_476743 Rpb1 CTD (4H8) Mouse,Cell Signaling Technology

(10) A novel Toxoplasma gondii TGGT1_316290 mRNA-LNP vaccine elicits protective immune response against toxoplasmosis in miceFrontiers in MicrobiologyMarch 21, 2023Dan Li, Yizhuo Zhang, Shiyu Li, Bin Zhengfrom Cell Signaling Technology, Inc. (Danvers, MA, United States) with the following catalog numbers: #5628 for IRF8, #13232 for T-bet, #8242 for NF-kB p65, and #4499 for H3 Histone. Statistical analysis GraphPad

(11) Human IRF1 governs macrophagic IFN-γ immunity to mycobacteriaCellFebruary 2, 2023Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z, Chan YH, Tahuil N, Türel Ö, et al.polyclonal),Santa Cruz,"Cat# sc-6058, RRID:AB_649510" Human IRF8 (clone D20D8),Cell signaling,"Cat# 5628, RRID:AB_10828231" Human IRF9 (rabbit polyclonal),Santa Cruz,"Cat# sc-496, RRID:AB_2127709" Human

(12) Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machineryNature CommunicationsDecember 1, 2022Tian Zhou et al.transferred to PVDF membranes and probed with antibodies directed against IRF8 (Cell Signaling Technology, 5628S, 1:1000 dilution), HRP-conjugated GAPDH (Abcam, AC035, 1:5000 dilution). GAPDH was used as a loading

(13) Transcriptional Plasticity Drives Leukemia Immune EscapeBlood cancer discoverySeptember 6, 2022Eagle K, Harada T, Kalfon J, Perez MW, Heshmati Y, Ewers J, Koren JV, Dempster JM, Kugener G, Paralkar VR, et al.(Supplementary Fig. S4A). The following antibodies were used: actin (Santa Cruz sc-47778), IRF8 (Cell Signaling 5628s), MEF2C (Cell Signaling 5030s), MYB (Abcam ab45150). A guide RNA targeting the AAVS1 “safe harbor” locus

(14) Pulmonary Alveolar Proteinosis and Multiple Infectious Diseases in a Child with Autosomal Recessive Complete IRF8 DeficiencyJournal of clinical immunologyJuly 1, 2022Rosain J, Bernasconi A, Prieto E, Caputi L, Le Voyer T, Buda G, Marti M, Bohlen J, Neehus AL, Castaños C, et al.(#1,704,159, Biorad). Membranes were probed with antibodies directed against IRF8 (unconjugated, clone D20D8, #5628, Cell Signaling), the V5 tag (HRP-coupled, Thermo Fisher Scientific), lamin A/C (HRP-conjugated, clone

(15) Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilitiesNature geneticsMay 1, 2022Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, et al.(#MA515738, clone GA1R, Thermo Fischer Scientific, 1:2000), Caspase-7 (#9492, Cell Signaling, 1:500), IRF8 (#5628S, clone D20D8, Cell Signaling, 1:500), Tubulin (#T5168, clone B-5–1-2, Sigma, 1:5000), HH3 (#702023,

(16) Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2Scientific ReportsDecember 1, 2021Bartolomeus J. Meijer et al.(Abcam, ab86281), anti-CDX1 (Abcam, ab126748), anti-MNX1 (Abcam, ab95926), anti-IRF8 (Cell Signaling, #5628), anti-c-MYC (Santa Cruz, sc-764), anti-CD44v6 (Biorad, #MCA1967), anti-TCF4 (Cell signaling, #2569S)

(17) Altered function and differentiation of age-associated B cells contribute to the female bias in lupus miceNature communicationsAugust 10, 2021Ricker E, Manni M, Flores-Castro D, Jenkins D, Gupta S, Rivera-Correa J, Meng W, Rosenfeld AM, Pannellini T, Bachu M, et al.complexes were used for immunoprecipitations with anti-IRF5 (Abcam #ab21689), anti-IRF8 (Cell Signaling; #5628), or normal anti-rabbit Ig control antibodies. DNA purified from the immunoprecipitates and inputs was

(18) Identification and characterization of B220(+)/B220(-) subpopulations in murine Gr1(+)CD11b(+) cells during tumorigenesisOncoimmunologyApril 14, 2021Zhang Z, Huang X, Wang E, Huang Y, Yang R.anti-S100A8 (CST; cat. no. 47310), rabbit anti-S100A9 (CST; cat. no. 73425), rabbit anti-IRF8 (CST; cat. no. 5628), and mouse anti-β-actin (Abcam, Cambridge, MA; cat. no. ab6276). All antibodies were used at a 1:1000

(19) Spleen Tyrosine Kinase Mediates Microglial Activation in Mice With Diabetic RetinopathyTranslational vision science & technologyApril 1, 2021Liu X, Xu B, Gao S.and then Western Blot was performed as previously described.11 All the antibodies used were Irf8 (#5628), Pu.1 (#2758), Syk (#13198), phosphor-Syk (#2710) (Cell Signaling Technology, Danvers, MA), cleaved

(20) Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune HepatitisFrontiers in immunologyJanuary 1, 2021Li B, Lian M, Li Y, Qian Q, Zhang J, Liu Q, Tang R, Ma X.Cell Signaling, Danvers, MA, USA), caspase-8 (#4790, Cell Signaling), PCNA (#13110, Cell Signaling), IRF-8 (#5628, Cell Signaling), and β-actin (#4970, Cell Signaling). Dual Luciferase Reporter Assay Briefly, 1 ×

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IRF-8 (D20D8) Rabbit mAb

IRF-8 (D20D8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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IRF-8 (D20D8) Rabbit mAb from Cell Signaling Technology

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