Anti-Cathepsin S antibodies are used for the immunodetection of the protein encoded by the CTSS gene. In humans, the canonical protein has a reported length of 331 amino acid residues and a mass of 37.5 kDa. Its subcellular localization is in the lysosomes, cytoplasmic vesicles, and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Peptidase C1 protein family, it is known to be involved with adaptive immune responses. Post-translational modifications have been described, including glycosylation. The cathepsin S marker can be used to characterize Fibroblastic Reticular Cells (FRC) and Monocytes.* Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 60 citations in the literature describe the use of Cathepsin S antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4