Anti-EPHA2 antibodies are used in the immunodetection of the protein EPH receptor A2. In humans, the canonical protein has a reported length of 976 amino acid residues and a mass of 108.3 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the brain and glioma tissue and glioma cell lines. A member of the Tyr protein kinase protein family, EphA2 is a known receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Synonyms for this target antigen include CTPA, CTPP1, CTRCT6, ECK, ephrin type-A receptor 2, and ARCC2. EPHA2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 400 citations in the literature describe the use of EphA2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Flow Cytometry are also common applications.