Anti-UPF3A antibodies are used in the immunodetection of the protein UPF3A regulator of nonsense mediated mRNA decay. In humans, the canonical protein has a reported length of 476 amino acid residues and a mass of 54.7 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the bronchus and nasopharynx. A member of the RENT3 protein family, UPF3A is known to be involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Synonyms for this target antigen include UPF3 regulator of nonsense transcripts homolog A, hUpf3, nonsense mRNA reducing factor 3A, up-frameshift suppressor 3 homolog A, and regulator of nonsense transcripts 3A. Some UPF3A antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.