Anti-HIWI antibodies are protein reagents that detect specific antigens. The HIWI antigen is another term for the human protein piwi like RNA-mediated gene silencing 1, encoded by the PIWIL1 gene. The protein is a reported endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Canonically, it has an amino acid length of 861 residues and a mass of 98.6 kilodaltons. Its subcellular localization is in the cytoplasm and it is reported to be expressed in spermatocytes and spermatids. The HIWI protein is a member of the Argonaute protein family. Other alias names for HIWI include CT80.1 and MIWI. ELISA, Western Blot, and Immunohistochemistry are common applications for HIWI antibodies.