Anti-SH3BP5 antibodies are used in the immunodetection of the protein SH3 domain binding protein 5. In humans, the canonical protein has a reported length of 455 amino acid residues and a mass of 50.4 kDa. Its subcellular localization is in the cytoplasmic vesicles, mitochondria, and membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in the testis and ovaries. A member of the SH3BP5 protein family, SH3BP5 is known to function as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. The SH3BP5 marker can be used to identify Gamma-Delta T Cells.* Synonyms for this target antigen include SH3 domain-binding protein that preferentially associates with BTK, SH3-domain binding protein 5 (BTK-associated), and SAB. SH3BP5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4