Anti-CHRM2 antibodies are used in the immunodetection of the protein cholinergic receptor muscarinic 2. In humans, the canonical protein has a reported length of 466 amino acid residues and a mass of 51.7 kDa. Its subcellular localization is in the cell membrane. It is notably widely expressed in many tissue types. A member of the G-protein coupled receptor 1 protein family, CHRM2 is known to be involved with chemical synaptic transmission and GPCR signaling pathways. Post-translational modifications have been described, including phosphorylation and glycosylation.
The CHRM2 marker can be used to identify Cerebral Cortex Interneurons.* Synonyms for this target antigen include muscarinic acetylcholine receptor M2, 7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor, and HM2. CHRM2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 100 citations in the literature describe the use of CHRM2 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4