Anti-PRSS57 antibodies are used in the immunodetection of the protein serine protease 57. In humans, the canonical protein has a reported length of 283 amino acid residues and a mass of 30.3 kDa. Its subcellular localization is in the cytoplasm and is secreted. It is notably expressed in peripheral blood neutrophil granulocytes, but not in other types of leukocytes. A member of the Peptidase S1 protein family, PRSS57 is reported to be a serine protease that cleaves preferentially after Arg residues. Post-translational modifications have been described, including N-glycosylation and protein cleavage.
The PRSS57 marker can be used to identify Early Erythroid Cells and Megakaryocytes-Erythroid-Mast Cells Progenitors (MEMP).* Synonyms for this target antigen include protease, serine 57, serine protease 1-like protein 1, and neutrophil serine protease 4. PRSS57 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Western Blot is a widely used application for the PRSS57 antibodies listed below. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4