Anti-HMCN1 antibodies are used in the immunodetection of the protein hemicentin 1. In humans, the canonical protein has a reported length of 5635 amino acid residues and a mass of 613.4 kDa. Its subcellular localization is in the extracellular matrix, cytoplasm, and is secreted. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in hair follicles and in the dermis. HMCN1 is known to be involved in transforming growth factor beta-mediated rearrangement of the podocyte cytoskeleton which includes reduction of F-actin fibers and broadening, flattening and elongation of podocytes. Post-translational modifications have been described, including glycosylation.
The HMCN1 marker can be used to identify Brain Vascular Non-Neuronal Cells, Midbrain-Derived Inhibitory Neurons, and Dorsal Excitatory Neurons.* Synonyms for this target antigen include LOC100507250/HMCN1 fusion and fibulin-6. HMCN1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some HMCN1 antibodies may have been used in research and have associated citations. Immunohistochemistry is a widely used application for these antibodies. Immunocytochemistry and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4