Anti-EPHB3 antibodies are used in the immunodetection of the protein EPH receptor B3. In humans, the canonical protein has a reported length of 998 amino acid residues and a mass of 110.3 kDa. Its subcellular localization is in the cell membrane. It is ubiquitously expressed across many tissue types. A member of the Tyr protein kinase protein family, EphB3 is a known receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Synonyms for this target antigen include ETK2, HEK2, TYRO6, ephrin type-B receptor 3, EPH-like tyrosine kinase 2, and EK2. EPHB3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of EphB3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.