Anti-PLA2G4A antibodies are used in the immunodetection of the protein phospholipase A2 group IVA. In humans, the canonical protein has a reported length of 749 amino acid residues and a mass of 85.2 kDa. Its subcellular localization is in the nucleus, Golgi, and cytoplasm. It is reported to be expressed in various cells and tissues such as macrophages, neutrophils, fibroblasts and lung endothelium. PLA2G4A is known to have primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response. Post-translational modifications have been described, including phosphorylation.
The PLA2G4A marker can be used to identify Deep-Layer Corticothalamic And 6B Neurons and Deep-Layer Intratelencephalic Neurons.* Synonyms for this target antigen include PLA2G4, cPLA2, cPLA2-alpha, cytosolic phospholipase A2, calcium-dependent phospholipid-binding protein, and GURDP. PLA2G4A gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4