Anti-CD5L antibodies are used in the immunodetection of the protein CD5 molecule like. In humans, the canonical protein has a reported length of 347 amino acid residues and a mass of 38.1 kDa. Its subcellular localization is in the cytoplasm and is secreted. It is reported to be expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues. CD5L is reported to be a secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis.
The CD5L marker can be used to identify Macrophages, Red Pulp Macrophages, Splenic Perifollicular Zone Macrophages, Tingible Body Macrophages, and Macrophagess.* Synonyms for this target antigen include API6, CT-2, PRO229, SP-ALPHA, Spalpha, hAIM, CD5 antigen-like, and AIM. CD5L gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. A number of CD5L antibodies have been mentioned in research publications and have associated citations. ELISA is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4