Anti-IRF7 antibodies are used in the immunodetection of the protein interferon regulatory factor 7. In humans, the canonical protein has a reported length of 503 amino acid residues and a mass of 54.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is reported to be highly expressed in spleen, thymus and peripheral blood leukocytes. A member of the IRF protein family, IRF7 is known to be involved with viral immune response and DNA damage pathways.
The IRF7 marker can be used to identify Thymic Plasmacytoid Dendritic Cells.* Synonyms for this target antigen include IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H, interferon regulatory factor-7H, and IMD39. IRF7 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 190 citations in the literature describe the use of IRF7 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4