Anti-CLDN8 antibodies are used in the immunodetection of the protein claudin 8. In humans, the canonical protein has a reported length of 225 amino acid residues and a mass of 24.8 kDa. Its subcellular localization is in the cell membrane. It is reported to be expressed in the epididymis, mainly in the caput segment. A member of the Claudin protein family, CLDN8 is known to be a tight-junction protein required for paracellular chloride transport in the kidney. Post-translational modifications have been described, including ubiquitination. Synonyms for this target antigen include HEL-S-79 and epididymis secretory protein Li 79. CLDN8 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of CLDN8 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.