Anti-Ezrin antibodies are used in the immunodetection of the protein encoded by the EZR gene. In humans, the canonical protein has a reported length of 586 amino acid residues and a mass of 69.4 kDa. It is reported to be expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. It is suspected to be involved in connections of major cytoskeletal structures to the plasma membrane. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include CVL, HEL-S-105, VIL2, cytovillin 2, epididymis secretory protein Li 105, p81, villin 2 (ezrin), and CVIL.