Anti-TOMT antibodies are used in the immunodetection of the protein transmembrane O-methyltransferase. In humans, the canonical protein has a reported length of 291 amino acid residues and a mass of 32.2 kDa. Its subcellular localization is in the ER and cytoplasm. Up to 2 different isoforms have been reported for this protein. , Tomt is known to catalyze the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). The TOMT gene has been associated with the disease, Deafness.