Anti-SCN4A antibodies are used in the immunodetection of the protein sodium voltage-gated channel alpha subunit 4. In humans, the canonical protein has a reported length of 1836 amino acid residues and a mass of 208.1 kDa. Its subcellular localization is in the cell membrane. A member of the Sodium channel (TC 1.A.1.10) protein family, SCN4A is reported to be a pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Post-translational modifications have been described, including phosphorylation and glycosylation. Synonyms for this target antigen include CMYP22A, HOKPP2, HYKPP, HYPP, NAC1A, Na(V)1.4, Nav1.4, and CMS16. SCN4A gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 180 citations in the literature describe the use of SCN4A antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.