Anti-GCL antibodies are used in antigen-specific immunodetection in biological samples. The target GCL is a known alias name of the protein glutamate-cysteine ligase catalytic subunit, encoded by the GCLC gene in humans. This 637-amino acid residue protein is known to catalyze the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. It is reported to be widely expressed in many tissue types. Western Blot is a widely used application for the GCL antibodies listed below. In addition, ELISA is also a common application.