Anti-PTN antibodies are used in the immunodetection of the protein pleiotrophin. In humans, the canonical protein has a reported length of 168 amino acid residues and a mass of 18.9 kDa. It has been described to be a secreted protein. It is notably expressed in the testis, pituitary gland, parathyroid gland, and cerebral cortex. A member of the Pleiotrophin protein family, PTN is known to be involved with nervous system development. Post-translational modifications have been described, including phosphorylation.
The PTN marker can be used to identify Type 1 Thymic Fibroblasts.* Synonyms for this target antigen include HB-GAM, HBBM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, and HARP. PTN gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PTN antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4