Anti-NAGS antibodies are used in the immunodetection of the protein N-acetylglutamate synthase. In humans, the canonical protein has a reported length of 534 amino acid residues and a mass of 58.2 kDa. Its subcellular localization is in the mitochondria. It is reported to be highly expressed in the adult liver, kidney and small intestine. A member of the Acetyltransferase protein family, NAGS is reported to play a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. The NAGS gene has been associated with the disease, N-acetylglutamate synthase deficiency. Synonyms for this target antigen include N-acetylglutamate synthase, mitochondrial and amino-acid acetyltransferase. NAGS gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Some NAGS antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.