Anti-SKP2 antibodies are used in the immunodetection of the protein S-phase kinase associated protein 2. In humans, the canonical protein has a reported length of 424 amino acid residues and a mass of 47.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the fallopian tube and placenta. SKP2 is reported to be a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Synonyms for this target antigen include FBXL1, FLB1, p45, CDK2/cyclin A-associated protein p45, F-box/LRR-repeat protein 1, and FBL1. SKP2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 290 citations in the literature describe the use of SKP2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.