Anti-RYR1 antibodies are used in the immunodetection of the protein ryanodine receptor 1. In humans, the canonical protein has a reported length of 5038 amino acid residues and a mass of 565.2 kDa. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the skeletal muscle, cerebral cortex, cerebellum, and caudate. A member of the Ryanodine receptor (TC 1.A.3.1) protein family, RYR1 is reported to be a calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Synonyms for this target antigen include CMYP1A, CMYP1B, KDS, MHS, MHS1, PPP1R137, RYDR, and CCO. RYR1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 500 citations in the literature describe the use of RYR1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.