Anti-FGFR3 antibodies are used in the immunodetection of the protein fibroblast growth factor receptor 3. In humans, the canonical protein has a reported length of 806 amino acid residues and a mass of 87.7 kDa. Its subcellular localization is in the cytoplasmic vesicles, ER, and cell membrane. Up to 4 different isoforms have been reported for this protein. It is reported to be expressed in the brain, kidney and testis. A member of the Tyr protein kinase protein family, FGFR3 is reported to be a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis.
The FGFR3 marker can be used to identify Gray Matter Astrocytes, Cerebral Cortex Astrocytes, and Brain Ependymal Non-Neuronal Cells.* Synonyms for this target antigen include CD333, CEK2, HSFGFR3EX, JTK4, fibroblast growth factor receptor 3-S, and ACH. FGFR3 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 160 citations in the literature describe the use of FGFR3 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4